588731-31-1

Basic information

• Product Name: 3-Pyridinecarbonitrile, 5-(3-chlorophenyl)-1,2-dihydro-6-methyl-2-oxo-
• CAS NO: 588731-31-1
• Molecular Formula: C13H9ClN2O
• Molecular Weight: 244.68
• Mol File: 588731-31-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 5-(3-chlorophenyl)-1,2-dihydro-6-methyl-2-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 5-(3-chlorophenyl)-1,2-dihydro-6-methyl-2-oxo-(588731-31-1)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 5-(3-chlorophenyl)-1,2-dihydro-6-methyl-2-oxo-(588731-31-1)

Safety Data

• Hazardous Substances Data: 588731-31-1(Hazardous Substances Data)

Upstream product

• 63503-60-6 3-chlorophenylboronic acid 
• 84725-13-3 5-bromo-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 4241-27-4 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile 

Downstream Products

• 641621-28-5 2-(tert-butyl-dimethyl-silanyloxy)-5-(3-chloro-phenyl)-6-methyl-nicotinonitrile 
• 588731-69-5 2-chloro-5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile 
• 588731-32-2 2-chloro-5-(3-chloro-phenyl)-6-hydroxymethyl-nicotinonitrile 
• 641621-29-6 5-(3-chloro-phenyl)-6-hydroxymethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 634588-71-9 2-chloro-5-(3-chloro-phenyl)-6-methyl-nicotinonitrile 

Relevant articles and documents

Pyridone-containing farnesyltransferase inhibitors: Synthesis and biological evaluation

Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed.