589-57-1 Usage
Description
DIETHYL CHLOROPHOSPHITE is a clear colorless to yellow liquid that is widely utilized in various chemical reactions and synthesis processes due to its unique properties as a phosphorylating agent.
Uses
1. Used in the Synthesis of Organophosphates:
DIETHYL CHLOROPHOSPHITE is used as a key intermediate for the synthesis of organophosphates, which are essential compounds in various applications, including pharmaceuticals and agrochemicals. These organophosphates are considered anticholinesterase agents, as observed in studies.
2. Used in Peptide Synthesis:
In the field of peptide chemistry, DIETHYL CHLOROPHOSPHITE serves as a valuable reagent for the synthesis of peptides. Its ability to act as a phosphorylating agent allows for the formation of peptide bonds, which are crucial for the structure and function of proteins.
3. Used as a Phosphorylating Agent:
DIETHYL CHLOROPHOSPHITE is used as a versatile phosphorylating agent for ester and lactone enolates, amines, and alkenols. This property makes it a valuable tool in the synthesis of a wide range of organic compounds, including those with potential applications in pharmaceuticals, materials science, and other industries.
4. Used in Pharmaceutical Industry:
DIETHYL CHLOROPHOSPHITE is used as a building block for the development of new pharmaceutical compounds, particularly those with anticholinesterase activity. These compounds have potential applications in the treatment of various neurological disorders, such as Alzheimer's disease and myasthenia gravis.
5. Used in Agrochemical Industry:
In the agrochemical industry, DIETHYL CHLOROPHOSPHITE is used in the synthesis of organophosphate-based pesticides. These pesticides are effective in controlling pests and protecting crops, contributing to increased agricultural productivity.
6. Used in Materials Science:
DIETHYL CHLOROPHOSPHITE is also utilized in the development of new materials with unique properties, such as self-healing materials and advanced polymers. Its role as a phosphorylating agent allows for the creation of novel structures and functionalities in these materials.
Check Digit Verification of cas no
The CAS Registry Mumber 589-57-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,8 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 589-57:
(5*5)+(4*8)+(3*9)+(2*5)+(1*7)=101
101 % 10 = 1
So 589-57-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H10ClO2P/c1-3-6-8(5)7-4-2/h3-4H2,1-2H3
589-57-1Relevant articles and documents
REACTION OF ESTERS OF N-BUTYL-N-ISOBUTENYLAMIDO- AND BIS(N-BUTYL-N-ISOBUTENYLAMIDO)PHOSPHORUS ACIDS WITH OXYGEN AND HALOGEN-CONTAINING COMPOUNDS
Kibardin, A.M.,Gryaznov, P.I.,Gazizov, T.Kh.,Pudovik, A.N.
, p. 2166 - 2168 (1984)
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CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES
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Page/Page column 71; 72, (2018/03/25)
Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
Synthetic method of methyl phosphite and glufosinate-ammonium
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Paragraph 0031; 0049, (2016/11/07)
The invention discloses a synthetic method of methyl phosphite and glufosinate-ammonium. The method comprises the steps: with phosphorus pentasulfide as a starting material, then carrying out vulcanization reaction, chlorination reaction, water washing and distillation purification, then carrying out catalytic hydrogenation to obtain chloride phosphite (III), and next carrying out Grignard reaction to obtain methyl phosphite (IV), wherein R is C1-C4 alkyl. The method comprises the steps: with phosphorus pentasulfide as the starting material, then carrying out vulcanization reaction, chlorination reaction, water washing and distillation purification, then carrying out catalytic hydrogenation to obtain chloride phosphite, next carrying out Grignard reaction to synthesize methyl phosphite (IV), and thus obtaining the final product glufosinate-ammonium through a Strecker route of the prior art. The synthetic yield is increased, methyl phosphorus dichloride and other unstable corrosive intermediates cannot be produced, the discharge of three-waste substances is reduced, and environment-friendly costs and pressure are reduced.
