58910-28-4

Basic information

• Product Name: ethyl (1-ethoxyethylidene)carbazate
• Synonyms: ethyl (1-ethoxyethylidene)carbazate;2-(1-Ethoxyethylidene)hydrazine-1-carboxylic acid ethyl ester
• CAS NO: 58910-28-4
• Molecular Formula: C₇H₁₄N₂O₃
• Molecular Weight: 174.19766
• EINECS: 261-492-2
• Mol File: 58910-28-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.07g/cm³
• Refractive Index: 1.454
• CAS DataBase Reference: ethyl (1-ethoxyethylidene)carbazate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (1-ethoxyethylidene)carbazate(58910-28-4)
• EPA Substance Registry System: ethyl (1-ethoxyethylidene)carbazate(58910-28-4)

Safety Data

• Hazardous Substances Data: 58910-28-4(Hazardous Substances Data)

Usage

General Description

Ethyl (1-ethoxyethylidene)carbazate is a chemical compound with the molecular formula C8H16N2O2. It is a carbazate derivative that is commonly used as a reagent in chemical reactions and synthesis processes. ethyl (1-ethoxyethylidene)carbazate is known for its applications in organic chemistry, particularly in the formation of hydrazones and as a building block for the preparation of various functionalized compounds. Ethyl (1-ethoxyethylidene)carbazate is often utilized in pharmaceutical research and drug development due to its versatile chemical reactivity and potential to form a wide range of derivatives with various biological activities. Its unique structure and properties make it a valuable intermediate for the synthesis of diverse organic molecules with potential applications in medicinal and industrial settings.

InChI:InChI=1/C7H14N2O3/c1-4-11-6(3)8-9-7(10)12-5-2/h4-5H2,1-3H3,(H,9,10)

Upstream product

• 2208-07-3 ethyl acetimidate hydrochloride 
• 4114-31-2 ethylhydrazine carboxylate 
• 1000-84-6 O-ethyl acetimidate 

Downstream Products

• 860612-43-7 2,4-dihydro-4-[4-(tert-butyl)phenyl]-5-methyl-3H-1,2,4-triazol-3-one 
• 1428154-56-6 4-(4-methylbenzoate)-5-methyl-3,4-dihydro-2H-1,2,4-triazol-3-one 
• 1426434-68-5 5-methyl-4-(4-benzoylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1269125-43-0 4-(3,5-dichlorophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1313389-78-4 4-[2-(3,4-dimethoxyphenyl)ethyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 860612-51-7 4-(4-bromophenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 182929-48-2 (3,5-Dimethyl-[1,2,4]triazol-4-yl)-carbamic acid ethyl ester 

Relevant articles and documents

Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties

Carbonic anhydrase enzymes (EC 4.2.1.1, CAs) are metalloenzyme families that catalyze the rapid conversion of H2O and CO2 to HCO3 – and H+. CAs are found in different tissues where they participate in various significant biochemical processes such as ion transport, carbon dioxide respiration, ureagenesis, lipogenesis, bone resorption, electrolyte secretion, acid-base balance, and gluconeogenesis. In such processes, many CAs are significant therapeutic targets because of their inhibitory potentials especially in the treatment of some diseases such as edema, glaucoma, obesity, cancer, epilepsy, and osteoporosis. Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are also valuable compounds for different therapeutic applications including Alzheimer's disease. In this work, we report a fast and effective synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one's aryl Schiff base derivatives and also their CA and cholinesterases inhibitory properties. Our findings showed that these Schiff base derivatives, with triazole ring, found as strong CA and cholinesterases inhibitors.