5892-99-9

Basic information

• Product Name: 4-BROMO-N,N-DIETHYLBENZAMIDE
• Synonyms: 4-BROMO-N,N-DIETHYLBENZAMIDE;N,N-Diethyl 4-bromobenzamide;N,N-DIETHYL-P-BROMOBENZAMIDE;BenzaMide, 4-broMo-N,N-diethyl-
• CAS NO: 5892-99-9
• Molecular Formula: C₁₁H₁₄BrNO
• Molecular Weight: 256.13896
• Product Categories: blocks;Bromides;Carboxes;alkyl bromide
• Mol File: 5892-99-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 61-66°C
• Boiling Point: 347.4°C at 760 mmHg
• Flash Point: 163.9°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 5.38E-05mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DCM, Ethyl Acetate
• CAS DataBase Reference: 4-BROMO-N,N-DIETHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-N,N-DIETHYLBENZAMIDE(5892-99-9)
• EPA Substance Registry System: 4-BROMO-N,N-DIETHYLBENZAMIDE(5892-99-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 5892-99-9(Hazardous Substances Data)

Usage

Description

4-BROMO-N,N-DIETHYLBENZAMIDE is an organic compound that serves as an intermediate in the synthesis of SNC 80 (S590000), a highly selective and potent non-peptide delta-opioid receptor agonist. It is characterized by its bromo and diethylamino substituents attached to a benzene ring, which contribute to its unique chemical properties and potential applications in pharmaceutical research.

Uses

Used in Pharmaceutical Research:
4-BROMO-N,N-DIETHYLBENZAMIDE is used as a key intermediate in the synthesis of SNC 80 (S590000), a highly selective and potent non-peptide delta-opioid receptor agonist. This makes it valuable for research and development of new drugs targeting the delta-opioid receptor, which has potential therapeutic applications in pain management and other conditions.
Used in Pain Management Research:
As a precursor to SNC 80, 4-BROMO-N,N-DIETHYLBENZAMIDE plays a crucial role in the development of novel pain management therapies. The delta-opioid receptor agonist SNC 80 has demonstrated high selectivity over other opioid receptors, which may lead to fewer side effects and a more targeted approach to pain relief.
Used in Drug Synthesis:
In the field of drug synthesis, 4-BROMO-N,N-DIETHYLBENZAMIDE is utilized as a building block for the creation of SNC 80 and potentially other related compounds. Its unique structure allows for the exploration of new chemical pathways and the development of innovative pharmaceutical agents.

InChI:InChI=1/C11H14BrNO/c1-3-13(4-2)11(14)9-5-7-10(12)8-6-9/h5-8H,3-4H2,1-2H3

Upstream product

• 201230-82-2 carbon monoxide 
• 589-87-7 1,4-bromoiodobenzene 
• 109-89-7 diethylamine 
• 121-44-8 triethylamine 
• 5467-74-3 4-Bromophenylboronic acid 
• 617-84-5 N-formyldiethylamine 
• 873-75-6 4-bromobenzenemethanol 
• 55441-26-4 2-(diethylamino)-2-oxoacetic acid 
• 374564-35-9 potassium 4-bromophenyltrifluoroborate 
• 586-75-4 4-chlorobenzoyl chloride 
• 78823-39-9 C₁₂H₁₃BrO₃ 
• 16532-79-9 4-Bromophenylacetonitrile 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 71888-24-9 4-(diethylaminocarbonyl)benzoic acid 
• 4885-19-2 1-(4-bromophenyl)-N,N-diethylmethanamine 
• 67055-76-9 4-benzoyl-N,N-diethylbenzamide 

Relevant articles and documents

Pd-Catalyzed Oxidative Aminocarbonylation of Arylboronic Acids with Unreactive Tertiary Amines via C-N Bond Activation

An efficient synthesis of tertiary amides from aryl boronic acids and inert tertiary amines through the oxidative carbonylation via C(sp3)-N bond activation is presented. This protocol significantly restricts the homocoupling biarylketone product. It involves the use of a homogeneous PdCl2/CuI catalyst and a heterogeneous Pd/C based catalyst, which promotes C(sp3)-N bond activation of tertiary amines with aryl boronic acids. This process represents a ligand-free, base-free, and recyclable catalyst along with an ideal oxidant like molecular oxygen.

Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages

The construction of amide bonds and peptide linkages is one of the most fundamental transformations in all life processes and organic synthesis. The synthesis of structurally ubiquitous amide motifs is essential in the assembly of numerous important molecules such as peptides, proteins, alkaloids, pharmaceutical agents, polymers, ligands and agrochemicals. A method of SO2F2-mediated direct clickable coupling of carboxylic acids with amines was developed for the synthesis of a broad scope of amides in a simple, mild, highly efficient, robust and practical manner (>110 examples, >90% yields in most cases). The direct click reactions of acids and amines on a gram scale are also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields.

NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel compound showing leukotriene B4 receptor 2 (BLT2) inhibitory activity and a pharmaceutical composition, for preventing or treating inflammatory diseases, comprising same as an active ingredient. The inventors identified a novel compound containing BTL2 inhibitory activity, and experimentally confirmed that the present novel compound had an excellent effect on the enhancement of the cancer cell death, on the inhibition of the metastasis and chemotactic mobility, and on the anti-asthma activity. Therefore, the present novel compound can be used as a very effective pharmaceutical component for treating the inflammatory-related diseases.