58928-28-2Relevant articles and documents
3-(PERFLUOROALKYL)PROPANAL PRODUCTION METHOD
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Paragraph 0033-0036; 0038-0061; 0063-0075; 0077-0079, (2018/10/31)
PROBLEM TO BE SOLVED: To provide a method of producing 3-(perfluoroalkyl)propanal with high selectivity, which is an important compound as a fluorine-containing building block for drug and functional material synthesis. SOLUTION: (Perfluoroalkyl)ethylene represented by the general formula (2) is reacted with carbon monoxide and hydrogen in the presence of a rhodium compound and diphosphine to produce 3-(perfluoroalkyl)propanal represented by the general formula (3). (In the formulas, Rf represents the same C1-16 perfluoroalkyl group.) COPYRIGHT: (C)2015,JPOandINPIT
Studies on the preparation of 2-(trifluoromethyl)acrylic acid and its esters from 3,3,3-trifluoropropene via hydrocarbonylation reactions
Botteghi, Carlo,Lando, Claudia,Matteoli, Ugo,Paganelli, Stefano,Menchi, Gloria
, p. 67 - 71 (2007/10/03)
The synthesis of methyl α-(trifluoromethyl)acrylate (MTFMA) has been carried out in three steps starting from commercially available 3,3,3,-trifluoropropene; this route involving the cobalt-catalyzed carbonylation of 2-bromo-3,3,3-trifluoropropene (2-Br-TFP) under very mild reaction conditions, gave only about 30% yield of the desired methyl ester. 2-(Trifluoromethyl)propanal, available in 90% yield by rhodium catalyzed hydroformylation of 3,3,3-trifluoropropene, proved to be an interesting starting product for the preparation of MTFMA: while the synthetic route involving the α-halogenation of 2-(trifluoromethyl)propanoic acid (TFMPA) failed to give any results, the reaction scheme based on the α-selenenylation of the above aldehyde followed by H2O2-oxidation afforded 68% yield of 2-(trifluoromethyl)acrylic acid (TFMAA).
Remarkable Dependency of Regioselectivity on the Catalyst Metal Species in the Hydroformylation of Trifluoropropene and Pentafluorostyrene
Fuchikami, Takamasa,Ojima, Iwao
, p. 3527 - 3529 (2007/10/02)
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