5896-50-4

Basic information

• Product Name: 1-(4-ethyl-2-hydroxyphenyl)ethanone
• Synonyms: 1-(4-ethyl-2-hydroxyphenyl)ethanone
• CAS NO: 5896-50-4
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• Mol File: 5896-50-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-ethyl-2-hydroxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ethyl-2-hydroxyphenyl)ethanone(5896-50-4)
• EPA Substance Registry System: 1-(4-ethyl-2-hydroxyphenyl)ethanone(5896-50-4)

Safety Data

• Hazardous Substances Data: 5896-50-4(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of 3-ethylphenyl acetate, ? with aluminium chloride, without solvent between 120° and 165° (80–88%), in nitrobenzene at 25° (84–89%) or at 60° (65%), in toluene or in xylene at 100° (56–57%); ? with titanium tetrachloride, without solvent at 120° (88%) or in nitrobenzene at 25° (66%) ; ? with stannic chloride, without solvent at 120° (84%) or in nitrobenzene at 25° (86%); ? with zinc chloride, without solvent at 120° (56%) or in nitrobenzene at 25° (58%).

Upstream product

• 31199-03-8 1,1-dimethoxypentan-3-one 
• 63446-76-4 1-methyl-1,3-bis(trimethylsilyloxy)buta-1,3-diene 
• 620-17-7 3-ethylphenol 
• 7446-70-0 aluminium trichloride 
• 3056-60-8 3-acetoxy-1-ethylbenzene 
• 98-95-3 nitrobenzene 
• 64-19-7 acetic acid 
• 27044-40-2 6-ethyl-2,3-dimethyl-benzofuran 

Downstream Products

• 876-20-0 2,5-diethyl phenol 
• 6068-60-6 3-(2,5-Diethyl-phenoxy)-butan-2-on 
• 108368-11-2 4-acetylamino-N-[4-(4-ethyl-2-hydroxy-phenyl)-thiazol-2-yl]-benzenesulfonamide 
• 108014-49-9 4-amino-N-[4-(4-ethyl-2-hydroxy-phenyl)-thiazol-2-yl]-benzenesulfonamide 
• 91970-44-4 1-<4-Aethyl-2-hydroxy-5-methoxy-phenyl>-aethan-1-on 
• 649551-68-8 7-ethyl-3-hydroxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 

Relevant articles and documents

Synthesis of functionalized salicylates by formal [3+3] cyclocondensation of 1,3-bis(silyloxy)buta-1,3-dienes with 3-alkoxy-2-en-1-ones

The formal [3+3] cyclization of 1,3-bis(silyloxy)buta-1,3-dienes with 1-aryl-3-ethoxyprop-2-en-1-ones, available by Heck reaction of benzoyl chlorides with ethyl vinyl ether, afforded a variety of 6-arylsalicylates. The reaction of the products with conce

Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: Assessment of potency, efficacy, and cardiovascular safety

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a chromone-2-carboxamide series as having excellent safety against the chosen cardiovascular endpoints at high drug concentrations in the plasma and brain. Optimization of this series led to considerable improvements in affinity, functional potency, and pharmacokinetic profile. This led to the identification of a 7-fluorochromone-2-carboxamide (22) that was orally efficacious in a diet-induced obese mouse model, retained a favorable cardiovascular profile in rat, and demonstrated dramatic improvement in effects on mean arterial pressure in our dog cardiovascular model compared to other series reported by our group. However, this analogue also led to prolongation of the QT interval in the dog that was linked to affinity for hERG channel and unexpectedly potent functional blockade of this ion channel.

FLAVONOID COMPOUNDS AS THERAPEUTIC ANTIOXIDANTS

Novel flavonoid compounds having anti-oxidant activity are described. The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a sunscreen or skincare composition or to treat conditions involving oxidative damage, especially curative or prophylactic treatment of Alzheimer's disease or ischaemia-reperfusion injury, is described.