58975-53-4

Basic information

• Product Name: Benzoic acid, 4-hydroxy-, 2-(aminothioxomethyl)hydrazide
• CAS NO: 58975-53-4
• Molecular Formula: C8H9N3O2S
• Molecular Weight: 211.244
• Mol File: 58975-53-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-hydroxy-, 2-(aminothioxomethyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-hydroxy-, 2-(aminothioxomethyl)hydrazide(58975-53-4)
• EPA Substance Registry System: Benzoic acid, 4-hydroxy-, 2-(aminothioxomethyl)hydrazide(58975-53-4)

Safety Data

• Hazardous Substances Data: 58975-53-4(Hazardous Substances Data)

Upstream product

• 99-96-7 4-hydroxy-benzoic acid 
• 333-20-0 potassium thioacyanate 
• 5351-23-5 4-hydroxybenzoic acid hydrazide 
• 1147550-11-5 ammonium thiocyanate 
• 28141-24-4 4-hydroxybenzoyl chloride 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 3414-96-8 5-p-hydroxyphenyl-4H-1,2,4-triazole-3-thiol 
• 3414-96-8 4-(3-mercapto-1H-1,2,4-triazol-5-yl)phenol 
• 3414-96-8 5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1174757-30-2 N'-(6-benzoyl-4-phenyl-2H-1,3-thiazin-2-ylidene)-(4'-hydroxyphenyl)hydrazide 
• 1402222-58-5 N'-(4,6-diphenylfuro[3,4-d]thiazol-2-yl)-4-hydroxybenzohydrazide 
• 4070-75-1 1,4-diphenyl-but-2-ene-1,4-dione 
• 1402222-51-8 (E)-((4,6-diphenylfuro[3,4-d]thiazol-2-yl)diazenyl)(4-hydroxyphenyl)methanone 
• 1022193-59-4 N'-(3-cyano-4-oxoindeno[1,2-b]pyrrol-2(4H)-ylidene)-4-hydroxybenzohydrazide 
• 1022193-55-0 N'-(3,3-dicyano-4-oxoindeno[1,2-b]pyrrol-2(1H,3H,4H)-ylidene)-4-hydroxybenzohydrazide 
• 1022193-73-2 C₂₄H₁₀N₈ 
• 1022193-71-0 4-hydroxy-N'-(2-amino-3-cyano)spiro[pyrrol-5-ylidenebenzohydrazide-4,1'-(cyclohexa-2',5'-dienylidene)]propanedinitrile 
• 1750-79-4 2-amino-5-(4'-hydroxyphenyl)-1,3,4-oxadiazole 
• 1022193-63-0 4-hydroxy-N'-(2H-thiazolo[5,4-b]indol-2-ylidene)benzohydrazide 
• 1022193-67-4 N'-(3-cyanopyrrolo[2,3-b]indol-2(1H)-ylidene)-4-hydroxybenzohydrazide 

Relevant articles and documents

Synthesis and invitro Evaluation of West Nile Virus Protease Inhibitors Based on the 2-{6-[2-(5-Phenyl-4H-{1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide Scaffold

In recent years, clinical symptoms resulting from West Nile virus (WNV) infection have worsened in severity, with an increased frequency in neuroinvasive diseases among the elderly. As there are presently no successful therapies against WNV for use in humans, continual efforts to develop new chemotherapeutics against this virus are highly desired. The viral NS2B-NS3 protease is a promising target for viral inhibition due to its importance in viral replication and its unique substrate preference. In this study, a WNV NS2B-NS3 protease inhibitor with a 2-{6-[2-(5-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide scaffold was identified during screening. Optimization of this initial hit by synthesis and screening of a focused compound library with this scaffold led to the identification of a novel uncompetitive inhibitor (1a24, IC50=3.4±0.2μM) of the WNV NS2B-NS3 protease. Molecular docking of 1a24 into the WNV protease showed that the compound interferes with productive interactions of the NS2B cofactor with the NS3 protease and is an allosteric inhibitor of the WNV NS3 protease.

Synthesis and antimicrobial activity of o- and p-hydroxybenzoic acid thiosemicarbazides

The ortho- and para-hydroxybenzoic acid thiosemicarbazide derivatives which are potentially biologically active substances were obtained by the reaction of the corresponding hydrazides with various isothiocyanates. Their structures were determined using I

Synthesis of some 2 arylideneamino 5 aryl 1,3,4 thiadiazoles as potential fungicides

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