59020-44-9

Basic information

• Product Name: 4-Phenylthiazole-2-carboxylic acid
• Synonyms: CHEMBRDG-BB 4401055;4-PHENYL-THIAZOLE-2-CARBOXYLIC ACID;4-PHENYL-1,3-THIAZOLE-2-CARBOXYLIC ACID;2-Thiazolecarboxylic acid,4-phenyl-;4-phenyl-1,3-thiazole-2-carboxylic acid(SALTDATA: FREE);4-phenyl-2-thiazolecarboxylic acid
• CAS NO: 59020-44-9
• Molecular Formula: C₁₀H₇NO₂S
• Molecular Weight: 205.23
• Product Categories: Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 59020-44-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 431.5 °C at 760 mmHg
• Flash Point: 214.8 °C
• Appearance: /
• Density: 1.368 g/cm³
• Vapor Pressure: 3.26E-08mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-Phenylthiazole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenylthiazole-2-carboxylic acid(59020-44-9)
• EPA Substance Registry System: 4-Phenylthiazole-2-carboxylic acid(59020-44-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 59020-44-9(Hazardous Substances Data)

Usage

General Description

4-Phenylthiazole-2-carboxylic acid is a chemical compound with the molecular formula C11H7NO2S. It is a thiazole derivative with a phenyl group attached to the thiazole ring. 4-Phenylthiazole-2-carboxylic acid is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical agents and drugs. It has also been studied for its potential biological activities, including antimicrobial and antifungal properties. Additionally, 4-Phenylthiazole-2-carboxylic acid has been investigated for its potential use in the development of new materials and as a precursor for the synthesis of bioactive compounds. Overall, this chemical compound has a diverse range of potential applications in the fields of medicine, materials science, and drug discovery.

InChI:InChI=1/C10H7NO2S/c12-10(13)9-11-8(6-14-9)7-4-2-1-3-5-7/h1-6H,(H,12,13)

Upstream product

• 75390-44-2 4-Phenyl-2-Thiazolecarboxaldehyde 
• 16982-21-1 ethyl 2-amino-2-thioxoacetate 
• 70-11-1 α-bromoacetophenone 
• 65384-99-8 2-hydroxymethyl-4-phenylthiazole 
• 98-86-2 acetophenone 
• 31877-30-2 ethyl 4-phenyl-1,3-thiazole-2-carboxylate 

Downstream Products

• 1231952-45-6 N-(2-(6-(morpholinomethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-4-phenylthiazole-2-carboxamide 
• 79247-92-0 methyl 4-phenylthiazole-2-carboxylate 
• 1826-12-6 4-phenyl-thiazole 

Relevant articles and documents

Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist

Farnesoid X receptor (FXR), a bile acid-activated nuclear receptor, regulates the metabolism of bile acid and lipids as well as maintains the stability of internal environment. FXR was considered as a therapeutic target of liver disorders, such as drug-induced liver injury, fatty liver and cholestasis. The previous reported FXR partial agonist 6 was a suitable lead compound in terms of its high potent and low molecular size, while the docking study of compound 6 suggested a large unoccupied hydrophobic pocket, which might be provided more possibility of structure-activity relationship (SAR) study. In this study, we have performed comprehensive SAR and molecular modeling studies based on lead compound 6. All of these efforts resulted in the identification of a novel series of FXR partial agonists. In this series, compound 41 revealed the best activity and strong interaction with binding pocket of FXR. Moreover, compound 41 protected mice against acetaminophen-induced hepatotoxicity by the regulation of FXR-related gene expression and improving antioxidant capacity. In summary, these results suggest that compound 41 is a promising FXR partial agonist suitable for further investigation.

FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR

The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

REGULATION OF PROTEIN SYNTHESIS

A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins