590365-63-2

Basic information

• Product Name: ethyl 2-diethylphosphono-2-fluoro-3-hydroxy-5-phenylpentanoate
• Synonyms: ethyl 2-diethylphosphono-2-fluoro-3-hydroxy-5-phenylpentanoate
• CAS NO: 590365-63-2
• Molecular Weight: 376.362
• Mol File: 590365-63-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-diethylphosphono-2-fluoro-3-hydroxy-5-phenylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-diethylphosphono-2-fluoro-3-hydroxy-5-phenylpentanoate(590365-63-2)
• EPA Substance Registry System: ethyl 2-diethylphosphono-2-fluoro-3-hydroxy-5-phenylpentanoate(590365-63-2)

Safety Data

• Hazardous Substances Data: 590365-63-2(Hazardous Substances Data)

Upstream product

• 645-45-4 hydrocinnamic acid chloride 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 590365-58-5 triethyl 2-fluoro-3-oxo-5-phenyl-2-phosphonopentanoate 

Downstream Products

• 211614-09-4 ethyl (Z)-2-fluoro-5-phenylpent-2-enoate 

Relevant articles and documents

Tandem reduction-olefination of triethyl 2-acyl-2-fluoro-2-phosphonoacetates and a synthetic approach to Cbz-Gly-Ψ[(Z)-CF{double bond, long}C]-Gly dipeptide isostere

(Z)-α-Fluoro-α,β-unsaturated esters (Z)-7a-f were stereoselectively prepared by a tandem reduction-olefination of triethyl 2-acyl-2-fluoro-2-phosphonoacetates 6a-f with NaBH4 in EtOH. A concise synthesis of Cbz-Gly-Ψ[(Z)-CF{double bond, long}C]-Gly (26) as a dipeptide isostere was achieved via the tandem reduction-olefination of the corresponding 2-acyl-2-fluoro-2-phosphonoacetate 20.