59108-43-9 Usage
General Description
8-Bromo-2-(trifluoromethyl)quinolin-4-ol is a chemical compound with the molecular formula C10H5BrF3NO. It is a derivative of quinoline and contains a bromine atom and a trifluoromethyl group attached to the quinoline ring. 8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL has potential applications in the pharmaceutical industry, as quinoline derivatives have been studied for their various biological activities, including antimicrobial, anticancer, and anti-inflammatory properties. The presence of the bromine and trifluoromethyl groups in 8-Bromo-2-(trifluoromethyl)quinolin-4-ol may also make it suitable for use as a building block in synthesis of other organic compounds. Additionally, due to its unique chemical structure, this compound may have potential for further research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 59108-43-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,1,0 and 8 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 59108-43:
(7*5)+(6*9)+(5*1)+(4*0)+(3*8)+(2*4)+(1*3)=129
129 % 10 = 9
So 59108-43-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H5BrF3NO/c11-6-3-1-2-5-7(16)4-8(10(12,13)14)15-9(5)6/h1-4H,(H,15,16)
59108-43-9Relevant articles and documents
QUINOLINE DERIVATIVES AS SMO INHIBITORS
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Paragraph 0281; 0282, (2017/02/28)
Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.
Selective and efficient structural elaboration of 2-(trifluoromethyl)quinolinones
Marull, Marc,Schlosser, Manfred
, p. 1576 - 1588 (2007/10/03)
The acid-catalyzed cyclization-condensation between anilines and ethyl 4,4,4-trifluoroacetoacetate affords 1,4-dihydro-2-trifluoromethyl-4H-4-quinolinones (1), which can easily be converted into 4-bromo-2-(trifluoromethyl)quinolines. These undergo halogen/metal exchange, generating 2-trifluoromethyl-4-quinolyllithiums, when treated with butyllithium, and hydrogen/metal exchange, generating 4-bromo-2-trifluoromethyl-3-quinolyllithiums, when treated with lithium diisopropylamide. Trapping of the latter intermediates provides 3-functionalized products that may be further elaborated by electrophilic substitution of the bromine atom. A few unexpected findings resulted from these investigations, the most noteworthy being an unprecedented buttressing effect and a counterintuitive halogen reactivity. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
