59168-21-7Relevant articles and documents
Synthesis of 3-Methyleneisoindolin-1-ones and Isoquinolinium Salts via Exo and Endo Selective Cyclization of 2-(1-Alkynyl)benzaldimines
Wang, Jiwei,Xie, Congyun,Cheng, Xiang,Liu, Ye,Zhang, Jun
, (2022/02/21)
Coinage metal-promoted 5-exo and 6-endo selective cyclization of 2-(1-alkynyl)benzaldimines has been studied. It was found that, under gold catalysis, 2-(1-alkynyl)benzaldimines exclusively underwent 5-exo-dig cyclization processes, followed by oxidation to form N-aryl 3-methyleneisoindolin-1-ones. In contrast, in the presence of base and under activation of AgOTf, switching of 5-exo to 6-endo cyclizations of 2-(1-alkynyl)benzaldimines was observed, exclusively giving N-aryl or N-alkyl substituted isoquinolinium salts. The two key reaction intermediates, exocyclic vinyl-Au and the endocyclic vinyl-Ag species have been isolated and characterized, and a study of their reactivities confirms the plausible mechanisms. Reactions of the resultant 3-methyleneisoindolin-1-ones with benzyne afforded structurally important isoindolinone-based benzocyclobutenes. Additionally, several interesting transformations of the resultant isoquinolinium salts have been investigated.
Co(iii)-catalysed regioselective linear C(8)-H olefination of isoquinolone with terminal aromatic and aliphatic alkynes
Chandra, Devesh,Gupta, Puneet,Kumar, Nikunj,Parmar, Diksha,Sharma, Upendra,Sumit
, p. 11613 - 11616 (2021/11/12)
A regioselective C8 linear olefination of isoquinoline-1H-2-one with terminal (aromatic and aliphatic) alkynes is reported under Co(iii) catalysis. This is an exclusive report on the C8 functionalization of isoquinolone using non-noble transition metal co
Oxidation of the inert sp3C-H bonds of tetrahydroisoquinolines through C-H activation relay (CHAR): construction of functionalized isoquinolin-1-ones
Yuan, Yuan,Zhang, Shuwei,Sun, Zheng,Su, Yichun,Ma, Qiyuan,Yuan, Yu,Jia, Xiaodong
supporting information, p. 3347 - 3350 (2021/04/07)
A TBN/O2-initiated oxidation of the relatively inert 3,4-C-H bonds of THIQs was accomplished, in which the existence of an α-phosphoric ester group is crucial to enable dioxygen trapping and intramolecular HAT (C-H activation relay,CHAR), reali