592-94-9Relevant articles and documents
Gram-Scale Preparation of Acyl Fluorides and Their Reactions with Hindered Nucleophiles
Barbasiewicz, Micha?,Tryniszewski, Micha?
supporting information, (2021/11/30)
A series of acyl fluorides was synthesized at 100 mmol scale using phase-transfer-catalyzed halogen exchange between acyl chlorides and aqueous bifluoride solution. The convenient procedure consists of vigorous stirring of the biphasic mixture at room temperature, followed by extraction and distillation. Isolated acyl fluorides (usually 7-20 g) display excellent purity and can be transformed into sterically hindered amides and esters when treated with lithium amide bases and alkoxides under mild conditions.
Analogs of 2-arachidonoylglycerin containing the no-donor group
Serkov,Gretskaya,Bezuglov
, p. 367 - 370 (2012/10/30)
1, 3-Dinitroglyceryl esters of fatty acids, analogs of endocannabinoid 2-arachidonoylglycerin, were synthesized. Various methods for esterifying fatty acids with glycerine dinitrate were developed.
A convenient, one-pot procedure for the preparation of acyl and sulfonyl fluorides using Cl3CCN, Ph3P, and TBAF(t -BuOH) 4
Kim, Joong-Gon,Jang, Doo Ok
experimental part, p. 3049 - 3052 (2011/02/25)
Various carboxylic acids were converted into acyl fluorides in excellent yields by treatment with trichloroacetonitrile, triphenylphosphine, and TBAF(t-BuOH)4 at room temperature. The reaction was applicable to the preparation of acid-sensitive amino acid fluorides without deprotection or rearrangement
