59223-78-8

Basic information

• Product Name: 1-(2-hydroxy-phenyl)3-(2-fluoro-phenyl)-propan-1-one
• Synonyms: 1-(2-hydroxy-phenyl)3-(2-fluoro-phenyl)-propan-1-one
• CAS NO: 59223-78-8
• Molecular Weight: 244.265
• Mol File: 59223-78-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-hydroxy-phenyl)3-(2-fluoro-phenyl)-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxy-phenyl)3-(2-fluoro-phenyl)-propan-1-one(59223-78-8)
• EPA Substance Registry System: 1-(2-hydroxy-phenyl)3-(2-fluoro-phenyl)-propan-1-one(59223-78-8)

Safety Data

• Hazardous Substances Data: 59223-78-8(Hazardous Substances Data)

Upstream product

• 1682-44-6 3-(2-fluorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 1439437-80-5 C₂₁H₂₆FNO₃ 
• 1443143-93-8 C₁₈H₁₇FO₃ 

Relevant articles and documents

Solvent-Controlled Hydrogenation of 2’-Hydroxychalcones: A Simple Solution to the Total Synthesis of Bussealins

A solvent-controlled hydrogenation of 2’-hydroxychalcones to selectively obtain different hydrogenation products is herein reported. Thus, hydrogenation of 2’-hydroxychalcones using EtOH as solvent provided the corresponding 1,3-diarylpropanes in excellent yields. On the contrary, when the hydrogenation was performed in DCM, the corresponding dihydrochalcones were isolated. Switching the reaction solvent to n-BuOH/H2O (1:1), afforded 1,3-diarylpropanols from moderate to good yields. The methodology here reported offers a straightforward, simple and cost-effective method for the preparation of a wide variety of 2’-hydroxy-1,3-diarylpropanes derivatives, and was also applied to the preparation of natural Bussealins C and D. (Figure presented.).