59227-79-1

Basic information

• Product Name: ethyl 4-(4-chlorophenoxy)butanoate
• Synonyms: ethyl 4-(4-chlorophenoxy)butanoate;4-(4-chlorophenoxy)butanoic acid ethyl ester;4-(p-chlorophenoxy)butanoic acid ethyl ester;ethyl 4-(p-chlorophenoxy)butanoate;4-(4-chloro-phenoxy)-butyric acid ethyl ester;4-(4-Chlor-phenoxy)-buttersaeure-aethylester
• CAS NO: 59227-79-1
• Molecular Formula: C₁₂H₁₅ClO₃
• Molecular Weight: 242.6987
• Mol File: 59227-79-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 340.1°Cat760mmHg
• Flash Point: 135.1°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 8.78E-05mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ethyl 4-(4-chlorophenoxy)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(4-chlorophenoxy)butanoate(59227-79-1)
• EPA Substance Registry System: ethyl 4-(4-chlorophenoxy)butanoate(59227-79-1)

Safety Data

• Hazardous Substances Data: 59227-79-1(Hazardous Substances Data)

Usage

Description

Ethyl 4-(4-chlorophenoxy)butanoate is a synthetic chemical compound derived from a natural compound found in chrysanthemum flowers. It is known for its potent insecticidal properties, which are achieved by disrupting the nervous systems of insects.

Uses

Used in Agricultural Industry:
Ethyl 4-(4-chlorophenoxy)butanoate is used as an insecticide for controlling pests on crops. Its effectiveness in disrupting the nervous systems of insects helps protect crops from damage and ensures a healthy yield.
Used in Public Health:
Ethyl 4-(4-chlorophenoxy)butanoate is used as an insect repellent in public health efforts to control disease-carrying insects such as mosquitoes. By disrupting their nervous systems, it helps prevent the spread of diseases like malaria, dengue, and Zika virus.
It is important to handle and use ethyl 4-(4-chlorophenoxy)butanoate with caution, as it can be toxic to humans and other non-target organisms if not used properly.

InChI:InChI=1/C12H15ClO3/c1-2-15-12(14)4-3-9-16-11-7-5-10(13)6-8-11/h5-8H,2-4,9H2,1H3

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 106-48-9 4-chloro-phenol 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 13997-70-1 1-allyloxy-4-chlorobenzene 
• 1007476-32-5 sodium ethyl acetylacetate enolate 

Downstream Products

• 3547-07-7 γ-(4-chlorophenoxy)-butyric acid 
• 6792-95-6 N,N-Diethyl-N'-<4-(4-chlor-phenoxy)-butyryl>-ethylendiamin 
• 107151-48-4 4-(4-chloro-phenoxy)-butyric acid-(2-diethylamino-ethyl ester) 

Relevant articles and documents

Novel 1,3,4-oxadiazole thioether derivatives containing flexible-chain moiety: Design, synthesis, nematocidal activities, and pesticide-likeness analysis

Seventy-two novel 1,3,4-oxadiazole thioether derivatives containing different flexible-chain moieties were designed and synthesized. The nematicidal activities of all the title compounds were evaluated, and some compounds showed excellent nematicidal acti

Synthesis and biological evaluations of some new oxadiazole–piperidine hybrid derivatives as antioxidant agents

A series of some new 1,3,4-oxadiazole-2-thiol derivatives (6a-h) containing cyclic secondary amine such as piperidine ring was expeditiously synthesized by alkylation of 1,3,4-oxadiazol-2-thiol derivatives with chloroethyl piperidine hydrochloride. The 1,3,4-oxadiazole-2-thiols were effectively synthesized by cyclization reaction of acid hydrazide derivatives with carbon disulfide. The target compounds 6a-h were preliminarily screened for in vitro antioxidant activities using various in vitro antioxidant assays including 2,2′-diphenyl-1-picrylhydrazyl, nitric oxide, and hydrogen peroxide methods. The results showed that the compounds exhibited promising antioxidant property in the three methods at 50, 75, and 100 μM. Among the tested compounds, the compounds 6a and 6b having chloro substituent in the benzene ring displayed greater radical scavenging activity.

CHEMCICAL COMPOUNDS

The invention is directed to substituted pyrrolidine derivatives. Specifically, the invention is directed to compounds according to Formula III: wherein A, B, L1, L2, L3, R1, R2, R3, R4, R5, R6, R9, R10, R30, Y1, Y2, z2, z4, z5, and z6 are as defined herein, and salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt-Jakob Disease, and related prion diseases, progressive supranuclear palsy, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, inflammation, fibrosis, chronic and acute diseases of the liver, chronic and acute diseases of the lung, chronic and acute diseases of the kidney, chronic traumatic encephalopathy (CTE), neurodegeneration, dementia, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.