59255-81-1

Basic information

• Product Name: O,O'-di-tert-butyl 4,4'-methylenebis(4,1-phenylene)dicarbamate
• Synonyms: O,O'-di-tert-butyl 4,4'-methylenebis(4,1-phenylene)dicarbamate
• CAS NO: 59255-81-1
• Molecular Weight: 398.502
• Mol File: 59255-81-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: O,O'-di-tert-butyl 4,4'-methylenebis(4,1-phenylene)dicarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: O,O'-di-tert-butyl 4,4'-methylenebis(4,1-phenylene)dicarbamate(59255-81-1)
• EPA Substance Registry System: O,O'-di-tert-butyl 4,4'-methylenebis(4,1-phenylene)dicarbamate(59255-81-1)

Safety Data

• Hazardous Substances Data: 59255-81-1(Hazardous Substances Data)

Upstream product

• 101-68-8 di(4-isocyanatophenyl)methane 
• 75-65-0 tert-butyl alcohol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 101-77-9 4,4'-diamino diphenyl methane 

Downstream Products

• 101-68-8 di(4-isocyanatophenyl)methane 

Relevant articles and documents

Synthesis and crystal structure determination of [H2-cryptand 222](Br3)2: A unique tribromide catalyst for the catalytic chemoselective N-boc protection of amines

The organic tribromide, [H2-cryptand 222](Br3) 2 was synthesized and characterized by X-ray crystallography, and was utilized as an active catalyst for the N-boc protection of amines. The method is general for the preparation of N-boc derivatives of aliphatic (acyclic and cyclic), aromatic, primary and secondary amines. We also applied our new reaction protocols for the N-boc protection of some new amines and spectral and physical data for the obtained products are reported.

PRODUCTION METHOD FOR AMIDATE COMPOUND

A method for producing an amidate compound represented by Formula (3), comprising reacting a urethane compound represented by Formula (1) with a carboxylate compound represented by Formula (2): (in the formulas, A, n, R1, R2, R3, R4, R5, R6, X, and a are as described in the Description).

Fluoride-Catalyzed Deblocking: A Route to Polymeric Urethanes

We report a fluoride-catalyzed deblocking of urethanes as “blocked” isocyanates. Organic and inorganic sources of fluoride ion proved effective for deblocking urethanes and for converting polyurethanes to small molecules. Distinct from conventional deblocking chemistry involving organometallic compounds and high temperatures, the method we describe is metal-free and operates at or slightly above room temperature. The use of fluorescent blocking agents enabled visual and spectroscopic monitoring of blocking/deblocking reactions, and the selected conditions proved applicable to urethanes containing a variety of blocking groups. The method additionally enabled a one pot deblocking and polymerization with α,ω-diols. Overall, this deblocking/polymerization strategy offers a convenient and efficient solution to problems that have limited the breadth of applications of polyurethane chemistry.

Nano-ferrous ferric oxide (nano-Fe3O4): Powerful, reusable, and stable catalyst for N-Boc protection of amines

Nano-ferrous ferric oxide (nano-Fe3O4) efficiently catalyzed N-boc protection of amines in high yields and acceptable reaction times. Nano-Fe3O4 was applied as an efficient, green, heterogeneous and reusable magnetite catalyst. Clean reaction, simple purification, short reaction time and high yield were some other advantages of this compound.