59272-24-1

Basic information

• Product Name: N-[(BENZYLAMINO)CARBONYL]-2-CHLOROACETAMIDE
• Synonyms: 1-benzyl-3-(2-chloroacetyl)urea
• CAS NO: 59272-24-1
• Molecular Formula: C₁₀H₁₁ClN₂O₂
• Molecular Weight: 226.66
• Mol File: 59272-24-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.269g/cm³
• Refractive Index: 1.553
• CAS DataBase Reference: N-[(BENZYLAMINO)CARBONYL]-2-CHLOROACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(BENZYLAMINO)CARBONYL]-2-CHLOROACETAMIDE(59272-24-1)
• EPA Substance Registry System: N-[(BENZYLAMINO)CARBONYL]-2-CHLOROACETAMIDE(59272-24-1)

Safety Data

• Hazardous Substances Data: 59272-24-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11ClN2O2/c11-6-9(14)13-10(15)12-7-8-4-2-1-3-5-8/h1-5H,6-7H2,(H2,12,13,14,15)

Upstream product

• 538-32-9 benzylurea 
• 79-04-9 chloroacetyl chloride 
• 4461-30-7 2-chloroacetylisocyanate 
• 100-46-9 benzylamine 

Downstream Products

• 85842-88-2 1-[2-(Acridin-9-ylsulfanyl)-acetyl]-3-benzyl-urea 

Relevant articles and documents

Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress

We prepared a series of quinoxalin-2-mercapto-acetyl-urea analogs and evaluated them for their ability to inhibit viral egress in our Marburg and Ebola VP40 VLP budding assays in HEK293T cells. We also evaluated selected compounds in our bimolecular complementation assay (BiMC) to detect and visualize a Marburg mVP40–Nedd4 interaction in live mammalian cells. Antiviral activity was assessed for selected compounds using a live recombinant vesicular stomatitis virus (VSV) (M40 virus) that expresses the EBOV VP40 PPxY L-domain. Finally selected compounds were evaluated in several ADME assays to have an early assessment of their drug properties. Our compounds had low nM potency in these assays (e.g., compounds 21, 24, 26, 39), and had good human liver microsome stability, as well as little or no inhibition of P450 3A4.