59361-08-9 Usage
Description
(4-Methylumbelliferyl)-N-acetyl-4,7,8,9-tetra-O-acetyl-a-D-neuraminic Acid, Methyl Ester is a complex organic compound with a unique chemical structure. It is characterized as a yellow amorphous solid and is known for its specific chemical properties that make it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
(4-Methylumbelliferyl)-N-acetyl-4,7,8,9-tetra-O-acetyl-a-D-neuraminic Acid, Methyl Ester is used as a substrate in a fluorometric assay of neuraminidase for the pharmaceutical industry. This application is crucial for the development and testing of new drugs targeting neuraminidase, an enzyme involved in the replication of certain viruses, including the influenza virus.
Used in Research and Diagnostic Applications:
In the field of research and diagnostics, (4-Methylumbelliferyl)-N-acetyl-4,7,8,9-tetra-O-acetyl-a-D-neuraminic Acid, Methyl Ester serves as a valuable tool for studying the activity and function of neuraminidase. Its use in fluorometric assays allows for the precise measurement of enzyme activity, which can be essential in understanding the underlying mechanisms of various diseases and the effectiveness of potential treatments.
Used in Chemical Synthesis:
(4-Methylumbelliferyl)-N-acetyl-4,7,8,9-tetra-O-acetyl-a-D-neuraminic Acid, Methyl Ester can also be utilized as a starting material or intermediate in the synthesis of other complex organic compounds. Its unique structure and functional groups make it a versatile building block for creating novel molecules with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 59361-08-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,3,6 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 59361-08:
(7*5)+(6*9)+(5*3)+(4*6)+(3*1)+(2*0)+(1*8)=139
139 % 10 = 9
So 59361-08-9 is a valid CAS Registry Number.
InChI:InChI=1/C30H35NO15/c1-14-10-25(37)44-22-11-20(8-9-21(14)22)45-30(29(38)39-7)12-23(41-17(4)34)26(31-15(2)32)28(46-30)27(43-19(6)36)24(42-18(5)35)13-40-16(3)33/h8-11,23-24,26-28H,12-13H2,1-7H3,(H,31,32)/t23?,24-,26?,27-,28?,30?/m1/s1
59361-08-9Relevant articles and documents
Facile anomer-oriented syntheses of 4-methylumbelliferyl sialic acid glycosides
Hassan, Abdullah A.,Oscarson, Stefan
supporting information, p. 6644 - 6649 (2021/08/10)
As part of a program to find new sialidases and determine their enzymatic specificity and catalytic activity, a library of 4-methylumbelliferyl sialic acid glycosides derivatised at the C-5 position were prepared fromN-acetylneuraminic acid. Both α- and β-4-methylumbelliferyl sialic acid glycosides were prepared in high yields and stereoselectivity. α-Anomers were accessedviareagent control by utilising additive CH3CN and TBAI, whereas the β-anomers were synthesised through a diastereoselective addition reaction of iodine and the aglycone to the corresponding glycal followed by reduction of the resulting 3-iodo compounds. Both anomer-oriented synthetic pathways allow for gram-scale stereoselective syntheses of the desired C-5 modified neuraminic acid derivatives for use as tools to quantify the enzymatic activity and substrate specificity of known sialidases, and potential detection and investigation of novel sialidases.
