59382-36-4

Basic information

• Product Name: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE
• Synonyms: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANAMINE;(RS)-1-[3-(Trifluoromethyl)phenyl]ethylamine 98%;(RS)-1-[3-(Trifluoromethyl)phenyl]ethylamine98%;1-(3-Trifluoromethylphenyl)ethylamine;1-[3-(Trifluoromethyl)phenyl]ethylamine, 3-(1-Aminoethyl)benzotrifluoride;alpha-Methyl-3-(trifluoromethyl)benzylamine 98%;(1S)-1-[3-(trifluoroMethyl)phenyl]ethan-1-aMine
• CAS NO: 59382-36-4
• Molecular Formula: C₉H₁₀F₃N
• Molecular Weight: 189.18
• Product Categories: Amines and Anilines
• Mol File: 59382-36-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: /
• Density: 1.18 g/cm³
• Storage Temp.: 2-8°C
• PKA: 8.72±0.10(Predicted)
• CAS DataBase Reference: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(59382-36-4)
• EPA Substance Registry System: (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(59382-36-4)

Safety Data

• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2734
• Hazardous Substances Data: 59382-36-4(Hazardous Substances Data)

Usage

General Description

(RS)-1-[3-(trifluoromethyl)phenyl]ethylamine is a chemical compound with the molecular formula C10H12F3N. It is a member of the class of compounds known as phenethylamines, which are organic compounds that contain a phenethylamine skeleton, consisting of a phenylethylamine moiety, with an ethylamine moiety at the alpha carbon. (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE is a colorless liquid at room temperature and is used in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the production of other organic compounds. Additionally, it has been found to have potential for use in medicinal chemistry, particularly in the development of new drugs for the treatment of various medical conditions.

Upstream product

• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 454-91-1 1-(3-trifluoromethylphenyl)ethanol 
• 402-24-4 3-(trifluoromethyl)styrene 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 

Downstream Products

• 791068-48-9 1-methyl-3-{[1-(3-trifluoromethyl-phenyl)ethylamino]methyl}-1H-quinoxalin-2-one 
• 1132803-44-1 2-(2-(phenylsulfonyl)ethylthio)-N-(1-(3-(trifluoromethyl)phenyl)ethyl)-nicotinamide 
• 1446770-50-8 N-[2-({1-[3-(trifluoromethyl)phenyl]ethyl}amino)-1H-benzimidazol-4-yl]acetamide 
• 959132-64-0 rac-2-[4-(4-chlorophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-N-{1-[3-(trifluoromethyl)phenyl]ethyl}acetamide 
• 959131-47-6 C₂₂H₂₀ClF₃N₄O₂ 
• 959130-95-1 2-[3-(4-chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-{1-[3-(trifluoromethyl)phenyl]ethyl}acetamide 
• 1020656-48-7 4-oxo-4-(1-(3-(trifluoromethyl)phenyl)ethylamino)butanoic acid 
• 903581-00-0 C₁₆H₁₅F₄NO₂S 

Relevant articles and documents

Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant

The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.

Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase

Chiral resolutions of trifluoroacetyl-derivatized 1-phenylalkylamines with different type and position of substituent were investigated by capillary gas chromatography by using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin diluted in OV-1701 as a chiral stationary phase. The influence of column temperature on retention and enantioselectivity was examined. All enantiomers of meta-substituted analytes as well as fluoro-substituted analytes could be resolved. Temperature had a favorable influence on enantioselectivity for small amines with substituents at the ortho-position. The type of substituent at the stereogenic center of amines also had a crucial effect as the ethyl group led to poor enantioseparation. Among all analytes studied, trifluoroacetyl-derivatized 1-(2′-fluorophenyl)ethylamine exhibited baseline resolution with the shortest analysis time.

Direct Synthesis of Primary Amines via Ruthenium-Catalysed Amination of Ketones with Ammonia and Hydrogen

A highly selective reductive amination of ketones to primary amines with ammonia and hydrogen using a simple ruthenium catalyst has been developed. The protocol described constitutes an efficient and direct atom-economical approach en route to α-methylbenzylamine derivatives in good to high yields. The presence of catalytic amounts of aluminum triflate turned out to be crucial for achieving high conversion towards primary amines.