5939-37-7 Usage
Description
7-Hydroxy Methotrexate is a naturally occurring metabolite of Methotrexate, a widely used antifolate drug. It possesses antineoplastic and antirheumatic properties, making it a valuable compound in the treatment of various diseases and conditions.
Used in Oncology:
7-Hydroxy Methotrexate is used as an antineoplastic agent for the treatment of cancer. It works by inhibiting the activity of dihydrofolate reductase, a key enzyme involved in the synthesis of DNA and RNA, thereby preventing the proliferation of cancer cells.
Used in Rheumatology:
7-Hydroxy Methotrexate is used as an antirheumatic drug for the management of autoimmune and inflammatory conditions, such as rheumatoid arthritis. It helps to reduce inflammation, pain, and swelling, improving the overall quality of life for patients with these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 5939-37-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,3 and 9 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5939-37:
(6*5)+(5*9)+(4*3)+(3*9)+(2*3)+(1*7)=127
127 % 10 = 7
So 5939-37-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N8O6/c1-28(8-12-18(32)26-16-14(23-12)15(21)25-20(22)27-16)10-4-2-9(3-5-10)17(31)24-11(19(33)34)6-7-13(29)30/h2-5,11H,6-8H2,1H3,(H,24,31)(H,29,30)(H,33,34)(H5,21,22,25,26,27,32)/t11-/m0/s1
5939-37-7Relevant articles and documents
Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10-deazaaminopterin
Dawson,O'Krongly,Hobbs,Barrueco,Sirotnak
, p. 635 - 638 (2007/10/02)
The potent folate antagonists methotrexate and 10-ethyl-10-deazaaminopterin are oxidized in vivo to their 7-hydroxy derivatives. A specific cyanation at the C-7 position of the pteridine ring system using diethyl phosphorocyanidate converted the dimethyl esters of methotrexate and 10-ethyl-10-deazaaminopterin to the corresponding 7-cyano dimethyl ester derivatives, which were hydrolyzed to the 7-hydroxy metabolites.