59394-30-8

Basic information

• Product Name: 6-CHLOROQUINOLINE-2-CARBOXYLIC ACID
• Synonyms: 6-CHLOROQUINOLINE-2-CARBOXYLIC ACID;AKOS A0602-0951;6-Chloro-2-quinolinecarboxylic acid
• CAS NO: 59394-30-8
• Molecular Formula: C₁₀H₆ClNO₂
• Molecular Weight: 207.61
• Mol File: 59394-30-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 228 °C
• Boiling Point: 382.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.469±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.45±0.43(Predicted)
• CAS DataBase Reference: 6-CHLOROQUINOLINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROQUINOLINE-2-CARBOXYLIC ACID(59394-30-8)
• EPA Substance Registry System: 6-CHLOROQUINOLINE-2-CARBOXYLIC ACID(59394-30-8)

Safety Data

• Hazardous Substances Data: 59394-30-8(Hazardous Substances Data)

Usage

General Description

6-Chloroquinoline-2-carboxylic acid is a chemical compound with the molecular formula C10H6ClNO2. It is a carboxylic acid derivative of quinoline, and it is commonly used in the synthesis of various pharmaceuticals and organic compounds. 6-CHLOROQUINOLINE-2-CARBOXYLIC ACID has been studied for its potential biological activities, including its antifungal and anti-inflammatory properties. It is also known for its use as a building block in the production of various drugs and agrochemicals. Additionally, 6-Chloroquinoline-2-carboxylic acid is used in the preparation of heterocyclic compounds and as a reagent in organic synthesis. Overall, this chemical serves as a valuable building block for the preparation of diverse organic compounds with potential pharmaceutical and industrial applications.

Upstream product

• 52313-35-6 6-chloroquinoline-2-carbonitrile 
• 612-57-7 6-chloroquinoline 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 57-60-3 piruvate 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 92-46-6 6-chloro-2-methylquinoline 
• 59394-26-2 6-chloroquinoline-2-carbaldehyde 

Downstream Products

• 480449-95-4 (1S,2R,4S)-N₂-(tert-Butoxycarbonyl)-N₁-[(6-chloro-quinolin-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine 

Relevant articles and documents

Repurposing an Aldolase for the Chemoenzymatic Synthesis of Substituted Quinolines

Quinoline derivatives are important natural products and pharmaceuticals, but their synthesis can be challenging due to poor yields, harsh reaction conditions, and instability of starting materials. Here we report the chemoenzymatic synthesis of quinaldic acids under mild conditions using an aldolase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (NahE, or HBPA). A series of 2-aminobenzaldehydes derived from reduction of the corresponding nitro analogue were reacted with pyruvate in the presence of NahE to give substituted quinolines in up to 93% isolated yield. This reaction differs from the aldol condensation catalyzed by NahE in vivo, instead resembling the heterocycle formation catalyzed by its homologue, dihydrodipicolinate synthase.

Synthesis of lodopyridone

The total synthesis of the unusual 4-pyridone marine metabolite lodopyridone has been achieved by late stage manipulation of the related 4-pyrone. Key reactions include a Suzuki-Miyaura coupling to form the tetracyclic core and a modified Corey-Ganem-Gilman reaction to install the ethanolamide side-chain.

5-Sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine

The invention concerns novel 5-sulphanyl-4H-1,2,4-triazole derivatives of formula (1), wherein: R1, R2 and R3 represent variable groups and the methods for preparing them by liquid-phase parallel synthesis processes. Said product exhibit good affinity for certain sub-types of somatostatin receptors; they are particularly useful for treating pathological conditions or diseases wherein one (or more) somatostatin receptors is (are) involved. The invention also concerns pharmaceutical compositions containing said products and their use for preparing a medicine.