594-65-0 Usage
Description
2,2,2-Trichloroacetamide is an aliphatic halogenated compound that is primarily recognized as a degradation product of trichloroacetonitrile. It is identified as a pollutant in the context of drinking water treatment. This off-white crystalline powder has garnered attention due to its presence in the environment and potential implications on public health.
Uses
Used in Environmental Studies:
2,2,2-Trichloroacetamide is used as a subject of research in environmental science for understanding its formation, behavior, and impact on ecosystems and human health. The study of this compound aids in developing strategies for mitigating its presence in drinking water and reducing its potential harmful effects.
Used in Water Treatment Industry:
In the water treatment industry, 2,2,2-Trichloroacetamide is used as a reference compound for assessing the effectiveness of treatment processes in removing harmful pollutants. By monitoring the levels of this compound, water treatment facilities can evaluate and improve their methods to ensure the delivery of clean and safe drinking water to the public.
Used in Regulatory Frameworks:
2,2,2-Trichloroacetamide serves as a parameter in regulatory frameworks that set standards for acceptable levels of pollutants in drinking water. It is used to establish guidelines and regulations that protect public health and the environment from the adverse effects of such contaminants.
Used in Analytical Chemistry:
As a compound with specific chemical properties, 2,2,2-Trichloroacetamide is used in analytical chemistry for the development and validation of methods to detect and quantify halogenated compounds in various environmental samples. This aids in the accurate measurement and monitoring of pollutants, contributing to a better understanding of their distribution and potential risks.
Safety Profile
Poison by intravenous route.Moderately toxic by ingestion and intraperitoneal routes.
Purification Methods
Its solution in xylene is dried with P2O5, then fractionally distilled. [Beilstein 2 IV 520.]
Check Digit Verification of cas no
The CAS Registry Mumber 594-65-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 594-65:
(5*5)+(4*9)+(3*4)+(2*6)+(1*5)=90
90 % 10 = 0
So 594-65-0 is a valid CAS Registry Number.
InChI:InChI=1/C2H2Cl3NO/c3-2(4,5)1(6)7/h(H2,6,7)
594-65-0Relevant articles and documents
Gilbert,E.E.
, p. 1801 - 1806 (1969)
Synthetic methodology towards allylic: Trans-cyclooctene-ethers enables modification of carbohydrates: Bioorthogonal manipulation of the lac repressor
Araman, Can,De Geus, Mark A. R.,Groenewold, G. J. Mirjam,Maurits, Elmer,Van Kasteren, Sander I.
, p. 10175 - 10179 (2020/10/13)
The inverse electron-demand Diels-Alder (IEDDA) pyridazine elimination is one of the key bioorthogonal bond-breaking reactions. In this reaction trans-cyclooctene (TCO) serves as a tetrazine responsive caging moiety for amines, carboxylic acids and alcohols. One issue to date has been the lack of synthetic methods towards TCO ethers from functionalized (aliphatic) alcohols, thereby restricting bioorthogonal utilization. Two novel reagents were developed to enable controlled formation of cis-cyclooctene (CCO) ethers, followed by optimized photochemical isomerization to obtain TCO ethers. The method was exemplified by the controlled bioorthogonal activation of the lac operon system in E. coli using a TCO-ether-modified carbohydrate inducer. This journal is
Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp3-Hybridized Carbon Atoms: Kinetic Resolution of β-Amino Alcohols by p-Methoxybenzylation
Kuroda, Yusuke,Harada, Shingo,Oonishi, Akinori,Kiyama, Hiroki,Yamaoka, Yousuke,Yamada, Ken-Ichi,Takasu, Kiyosei
supporting information, p. 13137 - 13141 (2016/10/30)
A catalytic strategy was developed for asymmetric substitution reactions at sp3-hybridized carbon atoms by using a chiral alkylating agent generated in situ from trichloroacetimidate and a chiral phosphoric acid. The resulting chiral p-methoxybenzyl phosphate selectively reacts with β-amino alcohols rather than those without a β-NH functionality. The use of an electronically and sterically tuned chiral phosphoric acid enables the kinetic resolution of amino alcohols through p-methoxybenzylation with good enantioselectivity.
