59446-75-2

Basic information

• Product Name: Galα(1->3)Galβ(1->4)GlcNAc
• CAS NO: 59446-75-2
• Molecular Weight: 545.495
• Mol File: 59446-75-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Galα(1->3)Galβ(1->4)GlcNAc(CAS DataBase Reference)
• NIST Chemistry Reference: Galα(1->3)Galβ(1->4)GlcNAc(59446-75-2)
• EPA Substance Registry System: Galα(1->3)Galβ(1->4)GlcNAc(59446-75-2)

Safety Data

• Hazardous Substances Data: 59446-75-2(Hazardous Substances Data)

Upstream product

• 57-50-1 sucrose 
• 3068-34-6 Acetic acid (2R,3S,4R,5R,6R)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-chloro-tetrahydro-pyran-4-yl ester 
• 188302-07-0 Acetic acid (2R,3R,4S,5S,6R)-5-acetoxy-6-acetoxymethyl-4-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yl ester 
• 70267-71-9 2,3,4,6-tetra-O-benzyl-1-O-(N-methylacetimidoyl)-β-D-galactopyranose 
• 77396-73-7 benzyl 2-acetamido-4-O-(2,6-di-O-benzyl-3,4-O-isopropylidene-β-D-galactopyranosyl)-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 77356-41-3 benzyl 2-acetamido-4-O-(2,6-di-O-benzyl-β-D-galactopyranosyl)-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 188302-05-8 Acetic acid (2R,3R,4S,5S,6R)-5-acetoxy-6-acetoxymethyl-2-(4-acetylamino-phenoxy)-4-((2R,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl ester 
• 80035-36-5 benzyl 3,6-di-O-benzyl-2-deoxy-2-phthalimido-beta-D-glucopyranoside 
• 4307-58-8 N-acetyl-D-lactosamine 
• 7493-95-0 4-nitrophenyl α-D-galactoside 
• 133-89-1 UDP-glucose 
• 47867-43-6 O-α-L-fucopyranosyl-(1<*>2)-3)>-O-β-D-galactopyranosyl-(1<*>4)-2-acetamido-2-deoxy-D-glucopyranose 
• 77356-44-6 benzyl 2-acetamido-4-O-<2,6-di-O-benzyl-3-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-β-D-galactopyranosyl>-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 83259-21-6 O-(2-O-Acetyl-3,4,6-tri-O-benzyl-α-D-mannopyranosyl)-(1-> 3)-O-(6-O-acetyl-2,4-di-O-benzyl-β-D-mannopyranosyl)-(1-> 4)-1,6-anhydro-2-azido-3-O-benzyl-2-desoxy-β-D-glucopyranose 

Relevant articles and documents

Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides

This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising α-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of α-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R3 is methoxy or methyl; R1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.

Glycosidase-catalysed synthesis of α-galactosyl epitopes important in xenotransplantation and toxin binding using the α-galactosidase from Penicillium multicolor

The α-galactosidase from Penicillium multicolor catalyses highly regioselective galactosyl transfer on to mono- and di-saccharide accepters that have a non-reducing terminal galactose unit to give products containing the α-D-Galp-(1→3)-D-Galp epitope found on pig tissue and which is responsible for the hyperacute rejection response in xenotransplantation of pig organs into man.

Chemoenzymatic synthesis of Galα1-3Gal, Galα1-3Galβ1-4GlcNAc, and their PEG-conjugates

Galα1-3Gal-pNP was prepared enzymatically from Gal-pNP using α-galactosidase from coffee beans. PEG was attached after the reduction of nitro group into amino group to give Galα1-3Gal-PEG conjugate. After removing the pNP group in Galα1-3Gal-pNP, the obtained disaccharide was used for the synthesis of Galα1-3Galβ1-4GlcNAc and corresponding trisaccharide-PEG conjugate.