59467-61-7

Basic information

• Product Name: [7-CHLORO-5-(2-FLUORO-PHENYL)-3H-BENZO[E][1,4]DIAZEPIN-2-YL]-METHYL-AMINE
• Synonyms: [7-CHLORO-5-(2-FLUORO-PHENYL)-3H-BENZO[E][1,4]DIAZEPIN-2-YL]-METHYL-AMINE;7-Chloro-5-(2-fluorophenyl)-N-methyl-3H-1,4-benzodiazepin-2-amine
• CAS NO: 59467-61-7
• Molecular Formula: C₁₆H₁₃ClFN₃
• Molecular Weight: 301.7459232
• Product Categories: Chemical Amines;Amines;Aromatics;Heterocycles
• Mol File: 59467-61-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 472.2°C at 760 mmHg
• Flash Point: 239.4°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 4.37E-09mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: [7-CHLORO-5-(2-FLUORO-PHENYL)-3H-BENZO[E][1,4]DIAZEPIN-2-YL]-METHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: [7-CHLORO-5-(2-FLUORO-PHENYL)-3H-BENZO[E][1,4]DIAZEPIN-2-YL]-METHYL-AMINE(59467-61-7)
• EPA Substance Registry System: [7-CHLORO-5-(2-FLUORO-PHENYL)-3H-BENZO[E][1,4]DIAZEPIN-2-YL]-METHYL-AMINE(59467-61-7)

Safety Data

• Hazardous Substances Data: 59467-61-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 59467-61-7 differently. You can refer to the following data:
1. A Diazepine derivative
2. A Diazepine derivative.

InChI:InChI=1/C16H13ClFN3/c1-19-15-9-20-16(11-4-2-3-5-13(11)18)12-8-10(17)6-7-14(12)21-15/h2-8H,9H2,1H3,(H,19,21)

Upstream product

• 2886-65-9 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one 
• 1645-32-5 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-thione 
• 74-89-5 methylamine 

Downstream Products

• 59467-62-8 7-chloro-5-(2-fluorophenyl)-2-(N-nitrosomethylamino)-3H-1,4-benzodiazepine 
• 819793-80-1 8?chloro?6?(2?fluorophenyl)?1?methyl?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine 
• 819793-75-4 8?chloro?6?(2?fluorophenyl)?3?(4?toluenesulfonyl)?4H?imidazo[1,5?a][1,4]benzodiazepine 
• 59467-70-8 Midazolam 

Relevant articles and documents

Preparation method of 7-chloro-5-(2-fluorophenyl)-3H-1, 4-benzodiazepin-2-methylamine

The invention provides a preparation method of 7-chloro-5-(2-fluorophenyl)-3H-1, 4-benzodiazepin-2-methylamine, which comprises the following steps: (1) reacting 7-chloro-5-(2-fluorophenyl)-1, 3-dihydro-2H-1, 4-benzodiazepin-2-one with phosphorus pentasulfide to obtain 7-chloro-5-(2-fluorophenyl)-1, 3-dihydro-2H-1, 4-benzodiazepin-2-thione, and (2) enabling the 7-chloro-5-(2-fluorophenyl)-1, 3-dihydro-2H-1, 4-benzodiazepin-2-thione to react with a methylamine alcohol solution, so as to prepare the 7-chloro-5-(2-fluorophenyl)-3H-1, 4-benzodiazepin-2-methylamine. The preparation method providedby the invention is low in cost, mild in condition, safe in production, high in yield, stable and reliable in product quality, simple and convenient to operate and more suitable for industrial production.

Reactions of 1,4-benzodiazepinic N-nitrosoamidines with tosylmethyl isocyanide: A novel synthesis of midazolam

Reaction of 1,4-benzodiazepinic N-nitrosoamidines, used as synthetic equivalents of imidoyl chlorides, with the monoanion of tosylmethyl isocyanide is described. The process gives entry to 3-(4-tosyl)imidazo[1,5-a][1,4] benzodiazepines, compounds which have not been described yet in the literature. These systems can be derivatized to the corresponding trisubstituted 1,4-benzodiazepines by alkylation or acylation of the imidazole ring. These new heterocyclic derivatives are potentially useful in the field of medicinal chemistry. In addition, midazolam 3, the anesthetic properties of which are well established, can be easily prepared in one step by desulfonylation of compound 7a.