59477-80-4Relevant articles and documents
Acylation of aryl halides and α-bromo acetates with aldehydes enabled by nickel/tbadt cocatalysis
Fan, Pei,Zhang, Chang,Zhang, Linchuan,Wang, Chuan
supporting information, p. 3875 - 3878 (2020/05/14)
In this protocol aryl halides and α-bromo acetates are efficiently cross-coupled with an array of (hetero)aromatic and aliphatic aldehydes under the cooperative catalysis of nickel and tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst. This method provides a concise approach to a variety of ketones with high compatibility of various functional groups.
Iodine promoted α-hydroxylation of ketones
Siddaraju, Yogesh,Prabhu, Kandikere Ramaiah
supporting information, p. 6749 - 6753 (2015/06/25)
A novel method for α-hydroxylation of ketones using substoichiometric amount of iodine under metal-free conditions is described. This method has been successfully employed in synthesizing a variety of heterocyclic compounds, which are useful precursors. α-Hydroxylation of diketones and triketones are illustrated. This strategy provides a novel, efficient, mild and inexpensive method for α-hydroxylation of aryl ketones using a sub-stoichiometric amount of molecular iodine.
Samarium diiodide induced reactions of cyclopropyl ketones: Reductive ring cleavage and dimerization leading to 1,8-diketones - Scope, limitations, mechanisms
Aulenta, Francesca,Hoelemann, Alexandra,Reissig, Hans-Ulrich
, p. 1733 - 1739 (2007/10/03)
Reactions of the samarium diiodide/HMPA complex with alkyl cyclopropyl ketones such as 3, 5, and 7 provided dimers incorporating a 1,8-diketone moiety. The products 4, 6, and 8 were isolated in moderate to good yields. The aryl-substituted cyclopropyl ketones afforded a broader product spectrum, which results from the attack of samarium intermediates to the aryl group. Cyclopropyl phenyl ketone (13) gave dimer 14, where one cyclopropane ring was reductively cleaved, whereas the second one is still present. The reductive dimerization of cyclopropyl 2-thienyl ketone (21) furnished the product 22, which still contains two cyclopropyl groups. Further examples demonstrate the diversity of samarium diiodide induced reductions of cyclopropyl ketones. Plausible reaction mechanisms involving samarium ketyl intermediates are presented. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.