594860-43-2Relevant articles and documents
Synthesis of Azole Nucleoside 5′-Monophosphate Mimics (P1Ms) and Their Inhibitory Properties of IMP Dehydrogenases
Wang, Guangyi,Sakthivel, Kandasamy,Rajappan, Vasanthakumar,Bruice, Thomas W.,Tucker, Kathleen,Fagan, Patrick,Brooks, Jennifer L.,Hurd, Tiffany,Leeds, Janet M.,Cook, P. Dan
, p. 317 - 337 (2007/10/03)
IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5′-MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases is not ass