59504-30-2

Basic information

• Product Name: 1-(2-chloro-6-nitrophenyl)pyrrolidine
• Synonyms: 1-(2-chloro-6-nitrophenyl)pyrrolidine
• CAS NO: 59504-30-2
• Molecular Weight: 226.663
• Mol File: 59504-30-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-chloro-6-nitrophenyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloro-6-nitrophenyl)pyrrolidine(59504-30-2)
• EPA Substance Registry System: 1-(2-chloro-6-nitrophenyl)pyrrolidine(59504-30-2)

Safety Data

• Hazardous Substances Data: 59504-30-2(Hazardous Substances Data)

Usage

Description

1-(2-chloro-6-nitrophenyl)pyrrolidine is a chemical compound with the molecular formula C12H11ClN2O2. It is a pyrrolidine derivative featuring a chlorine atom and a nitro group attached to the phenyl ring. This versatile chemical is known for its potential applications in the pharmaceutical and agrochemical industries, where it serves as a building block in the synthesis of various biologically active compounds. The presence of the nitro group in its structure also provides reactivity that can be utilized in organic synthesis.

Uses

Used in Pharmaceutical Industry:
1-(2-chloro-6-nitrophenyl)pyrrolidine is used as a building block for the synthesis of biologically active compounds. Its unique structure, which includes a chlorine atom and a nitro group, allows for the creation of a wide range of pharmaceutical products with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical field, 1-(2-chloro-6-nitrophenyl)pyrrolidine is used as a starting material for the development of new agrochemicals. Its reactivity and structural features make it a valuable component in the design and synthesis of compounds with pesticidal, herbicidal, or other agricultural applications.
Overall, 1-(2-chloro-6-nitrophenyl)pyrrolidine is a versatile and valuable chemical compound with diverse potential uses in the fields of medicine and agriculture, thanks to its unique structure and reactivity.

Upstream product

• 123-75-1 pyrrolidine 
• 3209-22-1 1,2-Dichloro-3-nitrobenzene 
• 2106-49-2 1-chloro-2-fluoro-3-nitrobenzene 

Downstream Products

• 58785-05-0 3-Chlor-2-pyrrolidinoanilin 

Relevant articles and documents

Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC

The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enables nucleophilic aromatic subsitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitate a broad functional group tolerance that can be utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent reveals the greenness and sustainability of the methodology presented herein.

Aromatic Nucleophilic Substitution of Halobenzenes with Amines under High Pressure

The nucleophilic substitution reactions of aromatic halides having electron-attracting groups on ortho or para position with various primary and secondary amines were accelerated by high pressure to give the corresponding N-substituted anilines in high yields.The bulkiness of amines affects its reactivity to lower the yields of the products.Although the secondary amines are usually less reactive than primary amines, cyclic secondary amines such as morpholine, piperidine, and pyrrolidine were found very reactive. 1,4-Diazabicyclooctane and quinuclidine gave N-quarternary ammonium halides in high yields in contrast to the low reactivity of acyclic tertiary amines.Dichloro- and trichloro-nitrobenzenes also react with diethylamine, pyrrolidine, and morpholine to give mono-, di-, and trisubstitution products depending upon the amount of amine and the position of nitro group in these chlorides.