59524-98-0

Basic information

• Product Name: 2-(4-chlorophenyl)-4-ethoxyquinazoline
• Synonyms: 2-(4-chlorophenyl)-4-ethoxyquinazoline
• CAS NO: 59524-98-0
• Molecular Weight: 284.745
• Mol File: 59524-98-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-4-ethoxyquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-4-ethoxyquinazoline(59524-98-0)
• EPA Substance Registry System: 2-(4-chlorophenyl)-4-ethoxyquinazoline(59524-98-0)

Safety Data

• Hazardous Substances Data: 59524-98-0(Hazardous Substances Data)

Upstream product

• 25563-14-8 4-chloro-N-methoxybenzamide 
• 825-60-5 benzimidic acid ethyl ester 
• 27032-10-6 4-chlorobenzyl azide 
• 132401-91-3 3-(4-chlorophenyl)-1,4,2-dioxazol-5-one 

Relevant articles and documents

Efficient Synthesis of Quinazolines from Aryl Imidates and N-Alkoxyamide by Ir(III)-Catalyzed C?H Amidation/Cyclization

An Ir(III) catalyst was used for the first time to realize the synthesis of quinazolines by C?H bond activation/cyclization with N-alkoxyamides as amidation reagents. This reaction has the advantages of wide substrate adaptability, good to excellent yield

Rh- and Cu-Cocatalyzed Aerobic Oxidative Approach to Quinazolines via [4 + 2] C-H Annulation with Alkyl Azides

A novel and efficient rhodium- and copper-co-catalyzed C-H bond activation and annulation for the construction of bioactively important quinazolines has been developed. This [4 + 2] annulation strategy utilizing alkyl azides as the carbon-heteroatom synthons shows high efficiency in the synthesis of six-membered benzoheterocycles containing two heteroatoms. This aerobic oxidative protocol provides a useful application of simple alkyl azides in N-heterocycle synthesis with N2 and H2O as byproducts.

Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.