59525-66-5

Basic information

• Product Name: (2S,5S)-1,4-dibenzoyl-2,5-dimethylpiperazine
• Synonyms: (2S,5S)-1,4-dibenzoyl-2,5-dimethylpiperazine
• CAS NO: 59525-66-5
• Molecular Weight: 322.407
• Mol File: 59525-66-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,5S)-1,4-dibenzoyl-2,5-dimethylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-1,4-dibenzoyl-2,5-dimethylpiperazine(59525-66-5)
• EPA Substance Registry System: (2S,5S)-1,4-dibenzoyl-2,5-dimethylpiperazine(59525-66-5)

Safety Data

• Hazardous Substances Data: 59525-66-5(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 98778-71-3 cis-(2S,5S)-2,5-dimethylpiperazine dihydrobromide 
• 59573-44-3 (+)-(2S,5S)-2,5-dimethylpiperazine 

Relevant articles and documents

Organic Chemistry of L-Tyrosine. 1. General Synthesis of Chiral Piperazines from Amino Acids

A new method for the conversion of optically active diketopiperazines (cyclo-dipeptides) into optically pure piperazines is described.Due to poor solubility of certain cyclo-dityrosine derivatives, the usual method using lithium aluminum hydride reaction was problematic, giving racemization under forcing conditions.However, the use of borane/tetrahydrofuran for this diketopiperazine to piperazine reduction proceeded well, affording high yields of optically pure materials.In this manner several mixed cyclo-dityrosine derivatives 9a-d were transformed into the piperazines 10a-d, potentially useful intermediates for the synthesis of the antibiotic alkaloids, piperazinomycin (1) and herquline (2).Finally, the naturally occuring alkaloid isolated from Zanthoxylum arborescens, 7b was prepared by this route.