595558-79-5

Basic information

• Product Name: Benzamide, N-(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-3,5-bis(1,1-dimethylethyl)-4-hydroxy-
• Synonyms: Benzamide, N-(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-3,5-bis(1,1-dimethylethyl)-4-hydroxy-
• CAS NO: 595558-79-5
• Molecular Formula: C₂₁H₃₀N₄O₄
• Molecular Weight: 402.49
• Mol File: 595558-79-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 234-236 °C
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 9.09±0.40(Predicted)
• CAS DataBase Reference: Benzamide, N-(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-3,5-bis(1,1-dimethylethyl)-4-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-3,5-bis(1,1-dimethylethyl)-4-hydroxy-(595558-79-5)
• EPA Substance Registry System: Benzamide, N-(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)-3,5-bis(1,1-dimethylethyl)-4-hydroxy-(595558-79-5)

Safety Data

• Hazardous Substances Data: 595558-79-5(Hazardous Substances Data)

Upstream product

• 3346-61-0 6-amino-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 1421-49-4 3,5-Di-tert-butyl-4-hydroxybenzoic acid 

Downstream Products

• 595559-14-1 1-(4-fluorophenyl)-3-methyl-6-methylamino-2,4-(1H,3H)-pyrimidinedione 
• 595558-86-4 5-(3,5-di-tert-butyl-4-hydroxyphenylcarboxamido)-1-(4-fluorophenyl)-3-methyl-6-methylamino-2,4-(1H,3H)-pyrimidinedione 
• 595559-18-5 5-amino-1-(4-fluoro-phenyl)-3-methyl-6-methylamino-1H-pyrimidine-2,4-dione 
• 595559-16-3 1-(4-fluoro-phenyl)-3-methyl-6-methylamino-5-nitroso-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction.

In order to obtain novel topically applied anti-inflammatory compounds containing an inexpensive anti-oxidative moiety without chirality, we synthesized compound 2c derivatives having a di-tert-butylphenol moiety, and evaluated by topical administration their anti-inflammatory potentials on picryl chloride-(PC) induced contact hypersensitivity reaction (CHR) in mice. In the course of our structure-activity relationship (SAR) studies on the pyrimidine or the anti-oxidative moiety and the linker between them, the most potent compounds (10, 11) were obtained by the insertion of a C2 unit in compound 2c. The potencies of these compounds were 2-fold greater than that of 1. Compounds 10 and 11 were considered to be useful lead compounds having inexpensive anti-oxidative moieties without chirality.