59564-29-3

Basic information

• Product Name: Phenol, 2-(4-phenyl-3-isoxazolyl)-
• CAS NO: 59564-29-3
• Molecular Formula: C15H11NO2
• Molecular Weight: 237.258
• Mol File: 59564-29-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phenol, 2-(4-phenyl-3-isoxazolyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-(4-phenyl-3-isoxazolyl)-(59564-29-3)
• EPA Substance Registry System: Phenol, 2-(4-phenyl-3-isoxazolyl)-(59564-29-3)

Safety Data

• Hazardous Substances Data: 59564-29-3(Hazardous Substances Data)

Upstream product

• 36838-59-2 N-styrylmorpholine 
• 94-67-7 salicylaldehyde-oxime 
• 119841-74-6 salicylhydroxamoyl chloride 
• 119841-73-5 2-(5-Morpholin-4-yl-4-phenyl-4,5-dihydro-isoxazol-3-yl)-phenol 

Downstream Products

• 120559-26-4 Acetic acid 2-(4-phenyl-isoxazol-3-yl)-phenyl ester 
• 574-12-9 isoflavone 
• 97904-75-1 isoflavanone 

Relevant articles and documents

ANTI-VIRAL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Disclosed herein are compounds and pharmaceutical compositions, and uses thereof for the treatment of viral infections, including RNA viral infections. The compounds, pharmaceutical compositions, and methods disclosed herein can relate to chromenone drug candidate compounds that modulate innate immunity along the RLR-IRF3 axis. These compounds activate innate immune signaling downstream of numerous viral countermeasures and are a unique addition to conventional antiviral compounds in development or on the market. These compounds possess broad spectrum in vitro activity against diverse RNA viruses including the respiratory pathogens influenza, RSV, and hCoV, with EC50 values in the low nanomolar range. Potent in vitro activity is also demonstrated against systemic and emerging viruses including Dengue and Ebola.