5957-97-1

Basic information

• Product Name: 3-(4-CHLORO-PHENYL)-PYRIDINE
• Synonyms: 3-(4-CHLORO-PHENYL)-PYRIDINE
• CAS NO: 5957-97-1
• Molecular Formula: C₁₁H₈ClN
• Molecular Weight: 189.64
• Mol File: 5957-97-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 310.7°C at 760 mmHg
• Flash Point: 170.7°C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 0.00108mmHg at 25°C
• Refractive Index: 1.588
• PKA: 4.71±0.10(Predicted)
• CAS DataBase Reference: 3-(4-CHLORO-PHENYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLORO-PHENYL)-PYRIDINE(5957-97-1)
• EPA Substance Registry System: 3-(4-CHLORO-PHENYL)-PYRIDINE(5957-97-1)

Safety Data

• Hazardous Substances Data: 5957-97-1(Hazardous Substances Data)

Usage

General Description

3-(4-chloro-phenyl)-pyridine is a chemical compound with the molecular formula C11H8ClN. It is a heterocyclic aromatic compound that consists of a pyridine ring substituted with a 4-chlorophenyl group. 3-(4-CHLORO-PHENYL)-PYRIDINE is used in the pharmaceutical industry as a building block in the synthesis of various pharmaceutical drugs and active pharmaceutical ingredients (APIs). It is also used as an intermediate in the production of agrochemicals and other fine chemicals. 3-(4-chloro-phenyl)-pyridine is a yellow solid with a characteristic odor and is typically handled and stored under strict chemical handling guidelines due to its toxic nature and potential hazards.

InChI:InChI=1/C11H8ClN/c12-11-5-3-9(4-6-11)10-2-1-7-13-8-10/h1-8H

Upstream product

• 1120-90-7 3-iodopyridine 
• 5575-51-9 tris(4-chlorophenyl)bismuthane 
• 626-55-1 3-Bromopyridine 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 106-39-8 bromochlorobenzene 
• 106-47-8 4-chloro-aniline 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1692-25-7 3-pyridylboronic acid 
• 626-60-8 3-Chloropyridine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 110-86-1 pyridine 
• 110213-25-7 C₆H₄ClN₂O^(1-)*Na⁽¹⁺⁾ 
• 56049-46-8 N’-(p-chlorophenyl) p-toluenesulfonyl hydrazide 
• 89878-14-8 3-Diethylboranylpyridine 

Downstream Products

• 929203-04-3 3-[4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyridine 
• 82261-42-5 4-pyridin-3-ylaniline 

Relevant articles and documents

Nickel-Catalyzed Amination of Aryl Chlorides with Amides

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.

Phenylpyridine derivative (by machine translation)

[Problem] in a photoelectric conversion element, the heat resistance can be improved phenylpyridine derivative. (1) Represented by the formula [a] phenylpyridine derivative (A ring, B, C D and is, a pyridine ring, each of the carbon atoms contained in R1 - R11, hydrogen, straight-chain alkyl group, a branched alkyl group, an aryl group, such as one selected from binding. ). Figure 1 [drawing] (by machine translation)

A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors

The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879.