5961-85-3 Usage
Description
Tris(2-carboxyethyl)phosphine, also known as tris(2-carboxyethyl)phosphane, is a tertiary phosphine compound in which the phosphane molecule is substituted with three 2-carboxyethyl groups. It is widely recognized for its reducing properties and is commonly utilized as a reducing agent in various chemical reactions and processes.
Uses
Used in Chemical Synthesis:
Tris(2-carboxyethyl)phosphine is used as a reducing agent for [facilitating various chemical reactions and processes] because of its strong reducing properties. It plays a crucial role in the synthesis of complex organic compounds and pharmaceuticals, where it helps in reducing specific functional groups to achieve the desired product.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, tris(2-carboxyethyl)phosphine is used as a reagent for [synthesizing various drugs and active pharmaceutical ingredients] due to its ability to act as a reducing agent. This property allows it to be employed in the production of a wide range of medications, contributing to the development of new and improved therapies.
Used in Analytical Chemistry:
Tris(2-carboxyethyl)phosphine is utilized as a reducing agent in [analytical chemistry applications] for the determination of various elements and compounds. Its reducing capabilities enable the simplification of complex samples, making it easier to analyze and identify specific components.
Used in Environmental Applications:
In environmental applications, tris(2-carboxyethyl)phosphine is used as a reducing agent for [treating contaminated water and soil samples] to remove or reduce the presence of harmful pollutants. Its ability to reduce specific contaminants makes it a valuable tool in environmental remediation efforts.
Used in Material Science:
Tris(2-carboxyethyl)phosphine is employed as a reducing agent in [the synthesis of advanced materials] such as polymers, nanoparticles, and other composites. Its reducing properties allow for the creation of novel materials with unique properties and applications in various industries, including electronics, energy, and aerospace.
Check Digit Verification of cas no
The CAS Registry Mumber 5961-85-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,6 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5961-85:
(6*5)+(5*9)+(4*6)+(3*1)+(2*8)+(1*5)=123
123 % 10 = 3
So 5961-85-3 is a valid CAS Registry Number.
5961-85-3Relevant articles and documents
Identification of a potent heterocyclic ligand to somatostatin receptor subtype 5 by the synthesis and screening of β-turn mimetic libraries
Souers, Andrew J.,Virgilio, Alex A.,Rosenquist, Asa,Fenuik, Wasyl,Ellman, Jonathan A.
, p. 1817 - 1825 (1999)
Methods for the parallel synthesis of medium-ring heterocyclic β-turn mimetics (1) are described, which enable the rapid preparation of libraries of mimetics for the identification of small molecule ligands to receptors. The generality of this method was first demonstrated by the rapid and high-yielding synthesis of mimetics 1a-g that display a wide range of proteinogenic amino acid side chains. Small molecule heterocyclic mimetics of the medicinally important peptide somatostatin were then identified by the synthesis of a focused library of β-turn mimetics based upon the crucial Trp-Lys motif found in the turn region of somatostatin. Screening the library against a panel of the five cloned human somatostatin receptors (hSST1-hSST5) resulted in the identification of a potent small molecule ligand (1h) with selectivity toward hSST5, as well as potent ligands toward receptor subtypes 1-4. Furthermore, structure-activity relationships were used to establish the importance of each of the three diversity inputs present in compound 1h. This investigation represents the first successful identification of potent, small molecule ligands through the synthesis and evaluation of a focused library of turn mimetics (for one example of a successful screening effort of a nonfocused β-turn library, see: Souers, A. J.; Virgilio, A. A.; Schuerer, S.; Ellman, J. A.; Kogan, T. P.; West, H. E.; Ankener, W.; Vanderslice, P. Bioorg. Med. Chem. Lett. 1998, 8, 2297-2302). The results of the library screening revealed unexpected stereochemical and functional group preferences, reinforcing the critical importance of synthesizing and evaluating collections of mimetics as opposed to traditional iterative synthesis and evaluation approaches. The ability to prepare libraries of heterocyclic turn mimetics that display three different side-chain inputs with multiple distinct side-chain orientations should enable the rapid identification of small molecule heterocyclic ligands to a large number of receptor targets.
