59618-42-7

Basic information

• Product Name: 5-hydroxy-1-methyl-5-(3-methylphenyl)pyrrolidin-2-one
• Synonyms: 2-pyrrolidinone, 5-hydroxy-1-methyl-5-(3-methylphenyl)-
• CAS NO: 59618-42-7
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 59618-42-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 391.8°C at 760 mmHg
• Flash Point: 190.8°C
• Density: 1.192g/cm³
• Vapor Pressure: 7.67E-07mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 5-hydroxy-1-methyl-5-(3-methylphenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-1-methyl-5-(3-methylphenyl)pyrrolidin-2-one(59618-42-7)
• EPA Substance Registry System: 5-hydroxy-1-methyl-5-(3-methylphenyl)pyrrolidin-2-one(59618-42-7)

Safety Data

• Hazardous Substances Data: 59618-42-7(Hazardous Substances Data)

Upstream product

• 59618-44-9 4-(3-methylphenyl)-4-oxobutanoic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 1121-07-9 N-methylsuccinimide 
• 28987-79-3 m-tolylmagnesium bromide 
• 591-17-3 meta-bromotoluene 

Relevant articles and documents

Synthesis of Chiral γ-Lactams via in Situ Elimination/Iridium-Catalyzed Asymmetric Hydrogenation of Racemic γ-Hydroxy γ-Lactams

Chiral γ-lactams have been synthesized in excellent yields and enantioselectivities (up to 99% yield and 96% ee) from easily accessible racemic γ-hydroxy γ-lactams via an iridium-phosphoramidite catalyzed asymmetric hydrogenation. The reaction was designed based on insight into the reaction mechanism demonstrated in previous work and can be carried out at a reduced catalyst loading of 0.1 mol % on a gram scale. Several potential bioactive compounds can be synthesized from the reduced products. Mechanistic studies indicated that the reduced products were obtained via the hydrogenation of the N-acyliminium cations, generated from γ-hydroxy γ-lactams.

5-Hydroxy-5-substituted phenyl-pyrrolidones and piperidinones

5-hydroxy-5-substituted phenyl-pyrrolidones and piperidinones, 3.g., 5-hydroxy-1-methyl-5-(m-trifluoromethylphenyl)pyrrolidone, are useful as sedative-hypnotic agents and minor tranquilizers.