5965-83-3

Basic information

• Product Name: 5-Sulfosalicylic acid dihydrate
• Synonyms: Benzoicacid,2-hydroxy-5-sulfo-,dihydrate;Salicylic acid, 5-sulfo-, dihydrate;5-Sulfosalicylic acid dihydrate, ACS, 99.0% min.;5-SULFOSALICYLIC ACID DIHYDRATE*ELEC;5-Sulfosalicylic acid dihydrate, p.a.;SULFOSALICYLIC-5 ACID;SULFOSALICYLIC ACID, DIHYDRATE;SULPHOSALICYLIC ACID
• CAS NO: 5965-83-3
• Molecular Formula: C7H10O8S
• Molecular Weight: 254.21
• EINECS: 202-555-6
• Product Categories: Rubber Chemicals;Organic acids
• Mol File: 5965-83-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 105-110 °C(lit.)
• Boiling Point: 705.7 °C at 760 mmHg
• Flash Point: 150°C
• Appearance: White/Powder
• Density: 0,8 g/cm3
• Vapor Density: 0.62 (vs air)
• Vapor Pressure: 6.63E-21mmHg at 25°C
• Storage Temp.: Store at RT.
• Solubility: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility: SOLUBLE
• Sensitive: Light Sensitive
• Stability: Stable, but light sensitive. Incompatible with strong oxidizing agents.
• Merck: 14,8964
• BRN: 650741
• CAS DataBase Reference: 5-Sulfosalicylic acid dihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Sulfosalicylic acid dihydrate(5965-83-3)
• EPA Substance Registry System: 5-Sulfosalicylic acid dihydrate(5965-83-3)

Safety Data

• Hazard Codes: Xn,C,Xi
• Statements: 22-36/37/38-34
• Safety Statements: 26-45-36/37/39-36
• RIDADR: UN 3261 8 / PGII
• WGK Germany: 3
• RTECS: VO6500000
• F: 8
• TSCA: Yes
• HazardClass: 8
• Hazardous Substances Data: 5965-83-3(Hazardous Substances Data)

Usage

Description

5-Sulfosalicylic acid dihydrate is a white crystalline powder that is a strong acid capable of protonating water. It forms 1:1 proton-transfer compounds with ortho-substituted monocyclic heteroaromatic Lewis bases, and its crystal structures have been studied using X-ray photoelectron spectroscopy (XPS). It is also known for its ability to reduce and fix proteins in agarose and polyacrylamide gels.

Uses

Used in Biochemistry:
5-Sulfosalicylic acid dihydrate is used as a reducing and fixing agent for proteins in agarose and polyacrylamide gels. This application is crucial in the process of protein electrophoresis, allowing for the separation and analysis of proteins based on their size and charge.
Used in Chemical Synthesis:
5-Sulfosalicylic acid dihydrate is used in the preparation of 1:1 proton-transfer organic adducts, such as 3-aminopyridinium 3-carboxy-4-hydroxy-benzenesulfonate monohydrate and the anhydrous adduct. These adducts are important in the synthesis of various chemical compounds and can be used in further research and development.
Used in Pharmaceutical Research:
The strong acidic properties of 5-sulfosalicylic acid dihydrate make it a valuable compound in the development of new pharmaceuticals. Its ability to form complexes with various Lewis bases can lead to the discovery of new drug candidates with potential therapeutic applications.
Used in Material Science:
The study of the crystal structures of 5-sulfosalicylic acid dihydrate and its proton-transfer compounds can contribute to the understanding of material properties and the development of new materials with specific characteristics. This knowledge can be applied in various industries, such as electronics, aerospace, and construction.
Used in Environmental Science:
The strong acidic nature of 5-sulfosalicylic acid dihydrate can be utilized in environmental applications, such as the treatment of wastewater or the removal of heavy metals from contaminated sites. Its ability to form complexes with various substances can help in the development of more efficient and eco-friendly solutions for environmental challenges.

Purification Methods

Crystallise the acid from H2O. Alternatively, it is converted to the monosodium salt which is crystallised from H2O and washed with a little H2O, EtOH and then Et2O. The acid is recovered by acidifying. The S-4-chlorobenzylisothiuronium salt has m 181o (from dioxane). [Beilstein 11 H 411, 11 II 232, 11 III 704.]

InChI:InChI=1/C7H6O6S.2H2O/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10;;/h1-3,8H,(H,9,10)(H,11,12,13);2*1H2