59656-60-9

Basic information

• Product Name: N-(4-(pyridin-4-yl)phenyl)acetamide
• Synonyms: N-(4-(pyridin-4-yl)phenyl)acetamide
• CAS NO: 59656-60-9
• Molecular Weight: 212.251
• Mol File: 59656-60-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(4-(pyridin-4-yl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(pyridin-4-yl)phenyl)acetamide(59656-60-9)
• EPA Substance Registry System: N-(4-(pyridin-4-yl)phenyl)acetamide(59656-60-9)

Safety Data

• Hazardous Substances Data: 59656-60-9(Hazardous Substances Data)

Upstream product

• 13296-04-3 4-(pyridin-4-yl)aniline 
• 19524-06-2 4-bromopyridine hydrochloride 
• 214360-60-8 N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 
• 622-50-4 4-Acetamido-1-iodobenzene 
• 113964-72-0 triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate 
• 103-88-8 4-bromoacetanilide 
• 25108-37-6 potassium pyridine-4-carboxylate 
• 106-40-1 4-bromo-aniline 
• 1692-15-5 4-pyridylboronic acid 

Downstream Products

• 861024-61-5 4-([1,1’-biphenyl]-4-yl)pyridine 
• 668435-29-8 N-(4-(1-methylpiperidin-4-yl)phenyl)acetamide 
• 668435-32-3 N-(4-(1-methylpiperidin-4-yl)-2-nitrophenyl)acetamide 
• 147293-18-3 2-bromo-4-(4-pyridinyl)benzenamine 
• 668423-23-2 4-(1-methylpiperidin-4-yl)-2-nitroaniline 
• 13296-04-3 4-(pyridin-4-yl)aniline 
• 1360452-74-9 C₁₅H₁₇N₂O⁽¹⁺⁾ 

Relevant articles and documents

Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts

Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

Palladium-catalyzed decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides

Decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides is reported. Using a bimetallic system of Cu2O and Pd(PPh3)4, the scope of the reaction is demonstrated by the synthesis of 27 pyridine-containing biaryls in moderate to good yields.

Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides

A number of isosteres (oxadiazoles, thiadiazoles, tetrazoles and diazines) of benzocaine were prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed within each series, with 1,2,4-oxadiazole 3 (metHb% = 61.0 ± 3.6) and 1,3,4-oxadiazole 10 (metHb% = 52.4 ± 0.9) demonstrating the greatest activity. Of the 5 candidates (compounds 3, 10, 11, 13 and 23) evaluated in vivo, failure to induce a lethal end-point at doses of 120 mg/kg was observed in all cases. Inadequate metabolic stability, particularly towards hepatic enzymes such as the CYPs, was postulated as one reason for their failure.