59660-95-6

Basic information

• Product Name: 2-amino-2-methylpropanoyl chloride hydrochloride
• CAS NO: 59660-95-6
• Molecular Formula: C₄H₈ClNO*ClH
• Molecular Weight: 158.02636
• Mol File: 59660-95-6.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-2-methylpropanoyl chloride hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-2-methylpropanoyl chloride hydrochloride(59660-95-6)
• EPA Substance Registry System: 2-amino-2-methylpropanoyl chloride hydrochloride(59660-95-6)

Safety Data

• Hazardous Substances Data: 59660-95-6(Hazardous Substances Data)

Usage

Color

Colorless

Odor

Pungent

Solubility

Soluble in water and organic solvents

Specific content

It is a hydrochloride salt derived from 2-amino-2-methylpropanoyl chloride
Widely used as an intermediate in the synthesis of pharmaceuticals and other organic compounds
Primary use in the production of various drugs in the pharmaceutical industry
Also used as a reagent in organic synthesis and chemical research

Upstream product

• 62-57-7 2-Aminoisobutyric acid 
• 2491-06-7 N,N-dimethylglycine hydrochoride 
• 5938-34-1 2-amino-2-methyl-propanoic acid hydrochloride 

Downstream Products

• 136928-41-1 2-(4-chlorophenyl)-4-(dimethylamino)acetyl-3,4-dihydro-2H-1,4-benzothiazine hydrochloride 
• 934526-89-3 N-(3-{[(2Z)-3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2(1H)-ylidene]sulfamoyl}phenyl)-2-methylalaninamide 
• 1205602-91-0 {1-[1-chloro-4-(4-fluoro-phenyl)-isoquinolin-3-ylcarbamoyl]-1-methyl-ethyl}-amide 
• 1205598-10-2 N-(2-Benzyl-5-phenyl-2H-pyrazol-3-yl)-2-[3-(2-chloro-phenyl)-ureido]-2-methyl-propionamide 
• 491585-34-3 (E)-3-[4-(2-amino-2-methyl-propanoylamino)-phenyl]-acrylic acid ethyl ester 

Relevant articles and documents

From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons

Replacement of the benzimidazole core of allosteric Thumb Pocket 1 HCV NS5B finger loop inhibitors by more lipophilic indole derivatives provided up to 30-fold potency improvements in cell-based subgenomic replicon assays. Optimization of C-2 substitution on the indole core led to the identification of analogs with EC50 100 nM and modulated the pharmacokinetic properties of the inhibitors based on preliminary data from in vitro ADME profiles and in vivo rat PK.

Phosphatidylinositol 3-Kinase Inhibitors for the Treatment of Lymphoproliferative Malignancies

Methods are provided for treating a lymphoproliferative malignancy to a patient in need of such treatment, comprising administering to the patient an effective amount of compound A as described herein.

TABLET FORMULATION OF A PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR

Methods are provided for treating cancer to a patient in need of such treatment, comprising administering a PI3K inhibitor.