59681-36-6

Basic information

• Product Name: 4-acetylhydrazinomethylene-2-phenyloxazol-5(4H)-one
• Synonyms: 4-acetylhydrazinomethylene-2-phenyloxazol-5(4H)-one
• CAS NO: 59681-36-6
• Molecular Weight: 245.238
• Mol File: 59681-36-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-acetylhydrazinomethylene-2-phenyloxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetylhydrazinomethylene-2-phenyloxazol-5(4H)-one(59681-36-6)
• EPA Substance Registry System: 4-acetylhydrazinomethylene-2-phenyloxazol-5(4H)-one(59681-36-6)

Safety Data

• Hazardous Substances Data: 59681-36-6(Hazardous Substances Data)

Upstream product

• 15646-46-5 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one 
• 1068-57-1 acetic acid hydrazide 

Downstream Products

• 109702-97-8 N-(3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-benzamide 
• 103-89-9 4-Methylacetanilide 
• 103-84-4 Acetanilid 
• 7197-01-5 6-chloro-3-methyl-1,2,4-triazolo<4,3-b>pyridazine 

Relevant articles and documents

4-Acylhydrazinomethylene-2-phenyloxazol-5(4H)-ones as acylating agents: Synthesis of salicylanilides and 1,2,4-triazolo[4,3-b] pyridazines

A simple and general method for the acylation of an amino or hydrazino group by the application of hydrazides has been developed. It starts from hydrazides (2), which are converted with 4-ethoxymethylene-2-phenyl-oxazol-5(4H)-one (1) to the corresponding 4-acylhydrazinomethylene-2-phenyloxazol-5(4H)-ones (3). The latter react with nitrogen-containing nucleophiles in 1,4-dioxane in the presence of triethylamine or zirconium(IV) chloride to give the corresponding amides (7) or mixtures of hydrazides (12) and 1,2,4-triazolo[4,3-b]pyridazines (11). Upon prolonged heating, compounds (11) are the main products.