59708-52-0

Basic information

• Product Name: Carfentanil
• Synonyms: 4-[(1-Oxopropyl)phenylamino]-1-(2-phenylethyl)-4-piperidinecarboxylic Acid Methyl Ester;Carfentanil;Carfentanyl;R 3183;4-Piperidinecarboxylic acid, 4-[(1-oxopropyl) phenylamino]-1-(2-phenylethyl), methyl ester ethanedioate;R 31833;1-[2-(Phenyl)ethyl]-4-(N-phenylpropanoylamino)piperidine-4β-carboxylic acid methyl ester;1-Phenethyl-4-[phenyl(propanoyl)amino]piperidine-4-carboxylic acid methyl ester
• CAS NO: 59708-52-0
• Molecular Formula: C₂₄H₃₀N₂O₃
• Molecular Weight: 394.512
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;PHARMACEUTICAL
• Mol File: 59708-52-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 508.1°C at 760 mmHg
• Flash Point: 261.1°C
• Appearance: /
• Density: 1.142
• Vapor Pressure: 1.91E-10mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Controlled Substance, -20°C Freezer
• PKA: 7.76±0.20(Predicted)
• CAS DataBase Reference: Carfentanil(CAS DataBase Reference)
• NIST Chemistry Reference: Carfentanil(59708-52-0)
• EPA Substance Registry System: Carfentanil(59708-52-0)

Safety Data

• Hazardous Substances Data: 59708-52-0(Hazardous Substances Data)

Usage

Description

Carfentanil is a potent synthetic opioid analgesic and is an analogue of Fentanyl. It is a controlled substance and acts as an opioid receptor agonist. Carfentanil is a monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of methyl 4-anilino-1-(2-phenylethyl)piperidine-4-carboxylate with propanoic acid. It is a pale yellow oil in its chemical form.

Uses

Used in Pharmaceutical Industry:
Carfentanil is used as an opioid receptor agonist for its potent analgesic effects. It is primarily utilized in veterinary medicine for its rapid onset and short duration of action, making it suitable for use in large animals that require anesthesia or pain management.
Used in Research and Development:
In the field of research, Carfentanil is used to study the effects of opioid receptor agonists on the central nervous system. Its high potency and selectivity for the mu-opioid receptor make it a valuable tool for understanding the mechanisms of opioid action and developing new therapeutic strategies for pain management.
Used in Controlled Substance Regulation:
As a controlled substance, Carfentanil is subject to strict regulations and monitoring to prevent its misuse and diversion for illicit purposes. Its high potency and potential for abuse make it a significant concern for law enforcement and public health officials, who work to ensure that it is used only for its intended medical and veterinary applications.

InChI:InChI=1/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3

Upstream product

• 498-94-2 isonipecotic acid 
• 100-42-5 styrene 
• 61085-55-0 methyl 4-(phenylamino)-1-(2-phenylethyl)-4-piperidinecarboxylate 
• 123-62-6 propionic acid anhydride 
• 807315-42-0 1-phenethyl-piperidine-4-carboxylic acid 
• 103-63-9 1-phenyl-2-bromoethane 
• 1159835-31-0 1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 62-53-3 aniline 
• 72996-78-2 methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate 
• 67-56-1 methanol 
• 1233201-80-3 C₂₉H₃₇N₃O₂ 

Relevant articles and documents

Synthetic method of anesthetic analgesic drug

The invention discloses a synthetic method of an anesthetic analgesic drug. According to the synthetic method, 4-piperidinecarboxylic acid is used as a raw material and subjected to alkylation, bromination, methylation, acylation and the like to prepare the anesthetic analgesic drug. The method avoids the usage of highly toxic cyanide, so the safety and controllability of operation are improved; the method avoids an elimination reaction in reaction process, thereby accelerating reaction speed and shortening reaction time; and the method reduces reaction temperature, shortens the reaction time,and is more suitable for industrial production.

Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil

A two-step sequence involving an Ugi four-component reaction was developed for the preparation of 4-aminopiperidine-4-carboxylic acid derivatives. This strategy has led to the successful preparation of two drugs carfentanil and remifentanil in shorter times and better yields than previously described methods.