59709-57-8 Usage
Description
6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE, also known as Salsolinol, is a compound derived from the neurotransmitter dopamine and acetaldehyde. It is present in various edibles and exists as R and S enantiomers, with R-salsolinol predominantly found in human brain tissue. Salsolinol is an off-white powder and has garnered interest due to its potential involvement in alcohol addiction and its effects on the metabolism of dopamine.
Uses
Used in Pharmaceutical Research:
6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is used as a research compound for studying its potential role in alcohol addiction. The application reason is that it is derived from acetaldehyde, a primary metabolite of ethanol in the liver, and might induce central changes in the metabolism of dopamine, which is associated with alcohol addiction.
Used in Neurochemical Studies:
In the field of neurochemistry, 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is used as a tool to investigate the interactions between dopamine and acetaldehyde in the brain. The application reason is to better understand the neurochemical mechanisms underlying alcohol addiction and potentially develop new therapeutic approaches.
Used in Analytical Chemistry:
6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is used as a reference compound in analytical chemistry for the detection and quantification of its enantiomers in various samples, such as food and biological tissues. The application reason is to determine the presence and concentration of R-salsolinol and S-salsolinol, which can provide insights into their potential effects on human health and behavior.
Used in Toxicology:
In toxicology, 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is used as a test compound to study its potential toxic effects on various biological systems. The application reason is to assess the risks associated with its presence in the human body, particularly in the context of alcohol consumption and addiction.
Used in Food Industry:
In the food industry, 6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is used as an analytical marker to monitor the presence of its enantiomers in various edibles. The application reason is to ensure food safety and quality by understanding the potential impact of these compounds on human health.
Used in Enantioselective Synthesis:
6,7-DIHYDROXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE is used as a starting material or intermediate in the enantioselective synthesis of chiral compounds. The application reason is to exploit the unique structural features of salsolinol to develop novel enantiomerically pure molecules with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.
Biochem/physiol Actions
Salsolinol, a neurotoxin, can serve as a prolactin-releasing factor and an etiological factor in the tuberoinfundibular pathway and in Parkinson′s disease (PD), respectively. It can also act as a modulator of catecholaminergic neurotransmission in the nigrostriatal pathway. In central nervous system, salsolinol can change the role of dopaminergic neurons and dopamine metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 59709-57-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,7,0 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 59709-57:
(7*5)+(6*9)+(5*7)+(4*0)+(3*9)+(2*5)+(1*7)=168
168 % 10 = 8
So 59709-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-6,11-13H,2-3H2,1H3/p+1/t6-/m1/s1
59709-57-8Relevant articles and documents
SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure
Dalence-Guzman, Maria F.,Berglund, Magnus,Skogvall, Staffan,Sterner, Olov
, p. 2499 - 2512 (2008/09/21)
Capsazepine as well as its derivatives and analogues are general inhibitors of constriction of human small airways. From a systematic variation of the capsazepine structure, divided into four regions, SARs were established. This part concerns the catechol moiety of the A-ring as well as the 2,3,4,5-tetrahydro-1H-2-azepine moiety (the B-ring) of capsazepine. It is revealed that a conformational constrain (as a fused ring) is important and that compounds with a six-membered B-ring (as a 1,2,3,4-tetrahydroisoquinoline) in general are more potent than the corresponding isoindoline, 2,3,4,5-tetrahydro-1H-2-benzazepine and 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.
