59727-98-9Relevant articles and documents
The effect of l-DOPA hydroxyl groups on the formation of supramolecular hydrogels
Zanna, Nicola,Iaculli, Debora,Tomasini, Claudia
, p. 5797 - 5804 (2017)
Fmoc-l-DOPA-d-Oxd-OH was prepared starting from commercially available l-DOPA. Its gelation ability was tested by comparison with Fmoc-l-Tyr-d-Oxd-OH and Fmoc-l-Phe-d-Oxd-OH using ten different triggers. Among them, only GdL, CaCl2 and ZnCl2 form strong hydrogels with the three gelators. The analysis of the aerogels obtained by freeze drying the hydrogels show that the three gelators always induce the formation of dense networks, which strongly depend on the nature of the gelator. Rheological analysis of these samples demonstrates that stronger gels were obtained using the l-Tyr containing gelator, while the l-DOPA containing hydrogels were characterized by a storage modulus approximately one order of magnitude lower. Finally, the l-Phe containing gelators show a different trend with respect to the other samples depending on the trigger used. All the hydrogels show a thixotropic behaviour at the molecular level. These results indicate that hydrogel formation is sensitive to both the number of the hydroxyl moieties on the aromatic rings and trigger used.
Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications
Herrmann, Andreas,Li, Bo,Li, Jingjing,Liu, Kai,Ma, Chao,Sun, Jing,Wang, Zili,Xiao, Lingling,Zhang, Hongjie,Zhao, Kelu,Zhou, Yu
, p. 23687 - 23694 (2021/10/08)
Adhesive hydrogels have been developed for wound healing applications. However, their adhesive performance is impaired dramatically due to their high swelling on wet tissues. To tackle this challenge, we fabricated a new type of non-swelling protein adhesive for underwater and in vivo applications. In this soft material, the electrostatic complexation between supercharged polypeptides with oppositely charged surfactants containing 3,4-dihydroxylphenylalanine or azobenzene moieties plays an important role for the formation of ultra-strong adhesive coacervates. Remarkably, the adhesion capability is superior to commercial cyanoacrylate when tested in ambient conditions. Moreover, the adhesion is stronger than other reported protein-based adhesives in underwater environment. The ex vivo and in vivo experiments demonstrate the persistent adhesive performance and outstanding behaviors for wound sealing and healing.
Large Amino Acid Transporter 1 Selective Liposomes of l -DOPA Functionalized Amphiphile for Combating Glioblastoma
Bhunia, Sukanya,Vangala, Venugopal,Bhattacharya, Dwaipayan,Ravuri, Halley Gora,Kuncha, Madhusudana,Chakravarty, Sumana,Sistla, Ramakrishna,Chaudhuri, Arabinda
, p. 3834 - 3847 (2017/11/15)
Despite significant progress in neurosurgery and radiation therapy during the past decade, overall survivability (OS) of glioblastoma patients continues to be less than 2 years. The scope of systemic chemotherapy is greatly limited by poor drug transport
