59749-37-0

Basic information

• Product Name: 1-(2,6-dichlorobenzyl)-5-oxo-L-proline
• CAS NO: 59749-37-0
• Molecular Formula: C₁₂H₁₁Cl₂NO₃
• Molecular Weight: 288.1266
• Mol File: 59749-37-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 519.6°C at 760 mmHg
• Flash Point: 268°C
• Density: 1.51g/cm³
• Vapor Pressure: 1.27E-11mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 1-(2,6-dichlorobenzyl)-5-oxo-L-proline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-dichlorobenzyl)-5-oxo-L-proline(59749-37-0)
• EPA Substance Registry System: 1-(2,6-dichlorobenzyl)-5-oxo-L-proline(59749-37-0)

Safety Data

• Hazardous Substances Data: 59749-37-0(Hazardous Substances Data)

Usage

Description

1-(2,6-dichlorobenzyl)-5-oxo-L-proline is a chemical compound that belongs to the family of proline derivatives. It is a white to off-white solid with a molecular formula C11H9Cl2NO3 and a molecular weight of 269.10 g/mol. This versatile chemical is often used in the synthesis of pharmaceuticals and as a building block in organic chemistry, playing a significant role in the development of various pharmaceutical and organic compounds.

Uses

Used in Pharmaceutical Synthesis:
1-(2,6-dichlorobenzyl)-5-oxo-L-proline is used as a building block for the synthesis of pharmaceuticals, particularly in the development of antiviral and antibacterial medications. Its unique structure and properties make it a valuable component in creating new and effective drugs to combat various diseases.
Used in Organic Chemistry:
In the field of organic chemistry, 1-(2,6-dichlorobenzyl)-5-oxo-L-proline is used as an intermediate in the production of various compounds with biological activity. Its versatility allows for its incorporation into a wide range of chemical reactions, leading to the creation of novel compounds with potential applications in various industries.
Used in Antiviral and Antibacterial Applications:
1-(2,6-dichlorobenzyl)-5-oxo-L-proline is also being studied for its potential therapeutic applications, particularly in the field of antiviral and antibacterial medications. Its ability to be incorporated into pharmaceutical compounds makes it a promising candidate for the development of new treatments against viral and bacterial infections.
Overall, 1-(2,6-dichlorobenzyl)-5-oxo-L-proline is a valuable chemical compound with a wide range of applications in the pharmaceutical and organic chemistry industries, as well as potential therapeutic uses in antiviral and antibacterial medications.

Upstream product

• 4931-66-2 methyl (S)-pyroglutamate 
• 59749-20-1 C₁₃H₁₃Cl₂NO₃ 
• 20443-98-5 2,6-Dichlorobenzyl bromide 

Downstream Products

• 1615249-92-7 tert-butyl ((R)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-67-6 C₂₃H₃₁Cl₂N₃O₄ 
• 1615249-91-6 tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 

Relevant articles and documents

Synthesis and identification of chiral aminomethylpiperidine carboxamides as inhibitor of collagen induced platelet activation

A series of chiral lactam carboxamides of aminomethylpiperidine were synthesized and investigated for the collagen induced in vitro anti-platelet efficacy and collagen plus epinephrine induced in vivo pulmonary thromboembolism. The compound 31a (30 μM/kg) displayed a remarkable antithrombotic efficacy (60% protection) which was sustained for more than 24 h and points to its excellent bioavailability. The compounds 31a (IC50 = 6.6 μM) and 32a (IC50 = 37 μM), as well as their racemic mixture 28i (IC50 = 16 μM) significantly inhibited collagen-induced human platelet aggregation in vitro. Compound 34c displayed dual mechanism of action against both collagen (IC50 = 3.3 μM) and U46619 (IC50 = 2.7 μM) induced platelet aggregation. The pharmacokinetic study of 31a indicated very faster absorption, prolonged and constant systemic exposure and thereby exhibiting better therapeutic response.