59756-83-1

Basic information

• Product Name: Benzeneacetyl chloride, 3-(phenylmethoxy)-
• CAS NO: 59756-83-1
• Molecular Formula: C15H13ClO2
• Molecular Weight: 260.72
• Mol File: 59756-83-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzeneacetyl chloride, 3-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetyl chloride, 3-(phenylmethoxy)-(59756-83-1)
• EPA Substance Registry System: Benzeneacetyl chloride, 3-(phenylmethoxy)-(59756-83-1)

Safety Data

• Hazardous Substances Data: 59756-83-1(Hazardous Substances Data)

Upstream product

• 1860-58-8 3-benzyloxyphenylacetic acid 
• 130604-43-2 ethyl 3-(benzyloxyphenyl)acetate 
• 22446-38-4 ethyl 3-hydroxyphenylacetate 
• 100-39-0 benzyl bromide 
• 79-37-8 oxalyl dichloride 
• 621-37-4 m-hydroxyphenylacetic acid 

Downstream Products

• 151841-47-3 (R)-6,7-dimethoxy-1-(3-hydroxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1316258-58-8 (S)-2,3-dimethoxy-9-hydroxyberbine 
• 1316259-19-4 (R)-1-(3-hydroxybenzyl)-6,7-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1316259-17-2 (S)-9-hydroxy-2,3-methylenedioxyberbine 
• 1316259-11-6 (R)-1-(3-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1316259-10-5 (S)-9-hydroxy-3-methoxyberbine 
• 1316259-15-0 (R)-1-(3-hydroxybenzyl)-2-methyl-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1316259-14-9 (S)-9-hydroxy-1,2,3-trimethoxyberbine 
• 1316259-22-9 (R)-1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1719-33-1 1-(3-hydroxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1871-08-5 1-(3-benzyloxybenzyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1213254-30-8 (R)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)propyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione 
• 1213255-07-2 (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)propyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione 
• 1213254-32-0 (R)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors

N-Acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme that catalyzes the hydrolysis of endogenous fatty acid ethanolamides (FAEs), such as N-palmitoylethanolamide (PEA). PEA exhibits anti-inflammatory and analgesic activities by engaging peroxisome proliferator-activated receptor α (PPAR-α). Preventing PEA degradation by inhibition of NAAA has been proposed as a novel strategy for the treatment of inflammation and pain. In the present study, we reported the discovery of the oxazolidone derivative as a novel scaffold for NAAA inhibitors, and studied the structure-activity relationship (SAR) by modification of the side chain and terminal lipophilic substituents. The results showed that the link chain length of C5, straight and saturated linkages were the preferred shape patterns for NAAA inhibition. Several nanomolar NAAA inhibitors were described, including 2f, 3h, 3i and 3j with IC50 values of 270 nM, 150 nM, 100 nM and 190 nM, respectively. Enzymatic degradation studies suggested that 2f inhibited NAAA in a selective, noncompetitive and reversible pattern. Moreover, 2f showed high anti-inflammatory and analgesic activities after systemic and oral administration.

Enantioselective Oxidative Aerobic Dealkylation of N-Ethyl Benzylisoquinolines by Employing the Berberine Bridge Enzyme

N-Dealkylation methods are well described for organic chemistry and the reaction is known in nature and drug metabolism; however, to our knowledge, enantioselective N-dealkylation has not been yet reported. In this study, exclusively the (S)-enantiomers o

Biocatalytic enantioselective oxidative C-C coupling by aerobic C-H activation

Bridging the gap: The berberine bridge enzyme (BBE) was employed for the first preparative oxidative biocatalytic C-C coupling that leads to a new intramolecular bond. This unique transformation requires O2 as sole stoichiometric oxidant and gives access to novel optically pure (S)-berbine 2 and (R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 1 alkaloid derivatives by kinetic resolution.