59759-67-0

Basic information

• Product Name: N-Benzoyl-α-cyclohexylglycine amide
• Synonyms: N-Benzoyl-α-cyclohexylglycine amide
• CAS NO: 59759-67-0
• Molecular Weight: 260.336
• Mol File: 59759-67-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-Benzoyl-α-cyclohexylglycine amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzoyl-α-cyclohexylglycine amide(59759-67-0)
• EPA Substance Registry System: N-Benzoyl-α-cyclohexylglycine amide(59759-67-0)

Safety Data

• Hazardous Substances Data: 59759-67-0(Hazardous Substances Data)

Upstream product

• 7471-86-5 methyl benzimidate 
• 108-94-1 cyclohexanone 
• 98-88-4 benzoyl chloride 
• 19508-15-7 2-phenyl-4-cyclohexylidene-2-imidazoline-5-one 
• 52956-46-4 4-cyclohexylidene-2-phenyloxazol-5(4H)-one 

Downstream Products

• 59759-91-0 N-benzoyl-α-cyclohexylglycine 
• 5664-29-9 2-cyclohexylglycine 

Relevant articles and documents

Practical and convenient enzymatic synthesis of enantiopure α-amino acids and amides

Catalyzed by the nitrile hydratase and the amidease in Rhodococcus sp. AJ270 cells under very mild conditions, a number of α-aryl- and α-alkyl-substituted DL-glycine nitriles 1 rapidly underwent a highly enantioselective hydrolysis to afford D-(-)-α-amino acid amides 2 and L-(+)-α-amino acids 3 in high yields with excellent enantiomeric excesses in most cases. The overall enantioselectivity of the biotransformations of nitriles originated from the combined effects of a high L-enantioselective amidase and a low enantioselective nitrile hydratase. The influence of the substrates on both reaction efficiency and enantioselectivity was also discussed in terms of steric and electronic effects. Coupled with chemical hydrolysis of D-(-)-α-phenylglycine amide, biotransformation of DL-phenylglycine nitrile was applied in practical scale to produce both D- and L-phenylglycines in high optical purity.

Synthesis of Acylamino Acid Amides and Acylamino Acids via 2,4-Disubstituted 2-Imidazolin-5-ones

Unsaturated 2,4-disubstituted 2-imidazolin-5-ones (I) have been reduced with a mixture of hydriodic acid and red phosphorus in the presence of acetic anhydride to give the saturated 2,4-disubstituted 2-imidazolin-5-ones (II) which have been hydrolysed to acylamino acid amides (III) and acylamino acids (IV) with sodium hydroxide solution under different conditions.In all six acylamino acid amides (23 - 51percent yields) and four acylamino acids (26 - 65percent yields) have been prepared.One saturated 2-imidazolin-5-one, namely 2-phenyl-4-benzyl-2-imidazolin-5-one has been isolated from the reaction in 40percent yield and identified.