5976-64-7

Basic information

• Product Name: Estrone 2,3-dimethyl ether
• Synonyms: Estrone 2,3-dimethyl ether
• CAS NO: 5976-64-7
• Molecular Weight: 314.425
• Mol File: 5976-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Estrone 2,3-dimethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: Estrone 2,3-dimethyl ether(5976-64-7)
• EPA Substance Registry System: Estrone 2,3-dimethyl ether(5976-64-7)

Safety Data

• Hazardous Substances Data: 5976-64-7(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 362-06-1 2-hydroxyestrone 

Downstream Products

• 362-08-3 2-methoxyestrone 
• 5976-63-6 2-Hydroxyestrone 3-methyl ether 
• 362-06-1 2-hydroxyestrone 
• 362-06-1 (+/-)-2,3-Dihydroxy-oestra-1,3,5⁽¹⁰⁾-trien-17-on 

Relevant articles and documents

Methylation of catechol estrogen with diazomethane

Dynamic aspects of methylation of catechol estrogen with diazomethane were investigated by means of thin-layer chromatography. The methylation rate of the hydroxyl group at the C-3 position was almost the same as that of the C-2 hydroxyl group in the reaction of 2-hydroxyestrogen, and 2-3 times that of the C-4 hydroxyl group in the reaction of 4-hydroxyestrogen. In these experiments, the maximum yields of 2-methoxyestrone, 2-hydroxyestrone 3-methyl ether, 4-methoxyesterone and 4-hydroxyesterone 3-methyl ether were 32, 39, 13, and 70%, respectively. In addition, demethylation of catechol estrogen dimethyl ethers with boron tribromide and synthesis of 4-hydroxyestrone monomethyl ethers are described.