59772-31-5Relevant articles and documents
High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex
Taylor, Isabelle R.,Dunyak, Bryan M.,Komiyama, Tomoko,Shao, Hao,Ran, Xu,Assimon, Victoria A.,Kalyanaraman, Chakrapani,Rauch, Jennifer N.,Jacobson, Matthew P.,Zuiderweg, Erik R.P.,Gestwicki, Jason E.
, p. 4014 - 4025 (2018/03/25)
Protein-protein interactions (PPIs) are an important category of putative drug targets. Improvements in high-throughput screening (HTS) have significantly accelerated the discovery of inhibitors for some categories of PPIs. However, methods suitable for s
THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS
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Page/Page column 113-114, (2008/06/13)
Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.