59777-67-2Relevant articles and documents
3-Functionalised benzenesulphonamide based 1,3,4-oxadiazoles as selective carbonic anhydrase XIII inhibitors: Design, synthesis and biological evaluation
Swain, Baijayantimala,Abhay,Singh, Priti,Angeli, Andrea,Aashritha, Kamtam,Nagesh, Narayana,Supuran, Claudiu T.,Arifuddin, Mohammed
, (2021/02/27)
A new series of benzenesulphonamide linked-1,3,4-oxadiazole hybrids (6a–s) has been synthesized and tested for their carbonic anhydrase inhibition against human (h) carbonic anhydrase (CA) isoforms hCA I, II, IX, and XIII. Fluorescence properties of some of the synthesized molecules were studied. Most of the molecules exhibited significant inhibitory power, comparable or better than the standard drug acetazolamide (AAZ) on hCA XIII. Out of 19 tested molecules, compound 6e (75.8 nM) was 3 times more potent than AAZ (250.0 nM) against hCA I, whereas compound 6e (15.4 nM), 6g (16.2 nM), 6h (16.4 nM) and 6i (17.0 nM) were found to be more potent than AAZ (17.0 nM) against isoform hCA XIII. It is anticipated that these compounds could be taken as the potential leads for the development of selective hCA XIII isoform inhibitors with improved potency.
SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY
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Page/Page column 508-509, (2020/08/13)
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: (Formula AA) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.
Aryl uracil compound or agriculturally acceptable salt and preparation method thereof and herbicide composition
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Paragraph 0121; 0125; 0127; 0129, (2019/02/03)
The invention provides an aryl uracil compound represented by a formula I (shown in the description) or agriculturally acceptable salt thereof. According to the formula I, R1 and R2 are independentlyselected from hydrogen, amino, C1-C4 alkyl or C1-C4 alkyl halide; X and Y are independently selected from hydrogen, halogen, nitryl, cyan, C1-C4 alkyl or substituted C1-C4 alkyl; R3 is selected from hydrogen, cyan or C1-C4 alkyl; and R4 is selected from cyan, nitryl, substituted or unsubstituted phenyl, substituted or unsubstituted five-membered or six-membered aromatic heterocyclic radical or a substituent group represented by a formula II (shown in the description), wherein R5 is selected from halogen, R6 and R7 are independently selected from hydrogen, halogen, C1-C4 alkyl or C1-C4 alkyl halide. The compound has the characteristics of wide weed control spectrum and high herbicidal activity. The invention further provides a preparation method of the aryl uracil compound or the agriculturally acceptable salt of the aryl uracil compound and a herbicide composition.
