598-35-6

Basic information

• Product Name: Propanal, 2-hydroxy-
• Synonyms: Propanal, 2-hydroxy-;Lactaldehyde;L-2-Hydroxypropionaldehyde;2-Hydroxypropionaldehyde;2-Hydroxypropanal solution;2-Hydroxypropionaldehyde solution;DL-Lactaldehyde solution
• CAS NO: 598-35-6
• Molecular Formula: C₃H₆O₂
• Molecular Weight: 74.07854
• Mol File: 598-35-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 121.9 °C at 760 mmHg
• Flash Point: 36.8 °C
• Appearance: /
• Density: 1.011 g/cm³
• Vapor Pressure: 6.82mmHg at 25°C
• Refractive Index: 1.396
• Storage Temp.: ?20°C
• PKA: 13.41±0.20(Predicted)
• BRN: 1719827
• CAS DataBase Reference: Propanal, 2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanal, 2-hydroxy-(598-35-6)
• EPA Substance Registry System: Propanal, 2-hydroxy-(598-35-6)

Safety Data

• Hazardous Substances Data: 598-35-6(Hazardous Substances Data)

Usage

Biochem/physiol Actions

D-Lactaldehyde is an intermediate in the pyruvate metabolic pathway. Pyruvaldehyde is irreversibly produced from D-lactaldehyde via the enzyme glyoxylate reductase. L-lactaldehyde is an intermediate metabolite in the pyruvate metabolism pathway and is irreversibly produced from pyruvaldehyde via the enzyme aldehyde reductase, which is then irreversibly converted to propylene glycol via aldehyde reductase.

InChI:InChI=1/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1

Upstream product

• 42919-42-6 (S)-1,1-dimethoxy-2-hydroxypropane 

Relevant articles and documents

Enzymatic vs. Fermentative Synthesis: Thermostable Glucose Dehydrogenase Catalyzed Regeneration of NAD(P)H for use in Enzymatic Synthesis

Procedures are described for regeneration of reduced nicotinamide cofactors NADH and NADPH from NAD(P) based on glucose and a thermostable glucose dehydrogenase from Bacillus cereus immobilized in polyacrylamide gels.The turnover number for NAD in a synthesis of 200 mmol of D-lactate is 40000.Application of this system to other syntheses is demonstrated with preparations of ethyl (R)-4-chloro-3-hydroxybutanoate, (R)-2,2,2-trifluoro-1-phenylethanol, ethyl (S)-3-hydroxyvalerate, (S)-lactaldehyde dimethyl acetal, and (S)-3-hydroxybutanal dimethyl acetal.Further investigation of the kinetics regarding the thermoresistance of glucose dehydrogenase in the presence of NaCl has been carried out, and it appears that the enhancement by NaCl of the thermal stability of the enzyme is approximately third order.The immobilized glucose dehydrogenase incubated at 55 deg C, pH 7.5, for 7 days is still fully active while many other enzymes are completely inactivated in 1-2 days.Addition of NaCl enhances the thermal stability more significantly than the immobilization does, and a remarkable increase in thermal stability was observed with these two combined factors.The half-life of the immobilized glucose dehydrogenase at 55 deg C in a buffer (pH 7.0-7.5) containing 1 M NaCl is more than 30 days compared to 3 min for the free enzyme, corresponding to an overall ca. 50000-fold increase in thermal stability.