59816-83-0

Basic information

• Product Name: Benzenamine, 4-methyl-2-(2-propenyl)-
• CAS NO: 59816-83-0
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Mol File: 59816-83-0.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-methyl-2-(2-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-methyl-2-(2-propenyl)-(59816-83-0)
• EPA Substance Registry System: Benzenamine, 4-methyl-2-(2-propenyl)-(59816-83-0)

Safety Data

• Hazardous Substances Data: 59816-83-0(Hazardous Substances Data)

Upstream product

• 15258-46-5 N-allyl-p-toluidine 
• 106-49-0 p-toluidine 
• 1219744-18-9 C₁₀H₁₁NO₂ 
• 14618-59-8 N-(tert-butoxycarbonyl)-4-methylaniline 

Downstream Products

• 1251443-46-5 2-(iodomethyl)-5-methyl-1-tosylindoline 
• 1380538-75-9 (S)-2-(iodomethyl)-5-methyl-1-tosylindoline 
• 1609653-39-5 benzyl 5-methyl-2-(2,2,2-trifluoroethyl)indoline-1-carboxylate 
• 1609653-14-6 C₁₈H₁₉NO₂ 
• 150596-82-0 N-benzyl-2-(2-propenyl)aniline 
• 116436-12-5 4-methyl-2-propyl-aniline 
• 66236-12-2 N-(2-allyl-4-methylphenyl)methanesulfonamide 
• 1418217-96-5 2-allyl-4-methyl-N-(prop-2-ynyl)aniline 
• 1391726-88-7 C₁₉H₂₁N 
• 1391727-02-8 C₁₉H₁₆F₃NO 

Relevant articles and documents

Synthesis of functionalized indoles via palladium-catalyzed cyclization of N-(2-allylphenyl) benzamide: A method for synthesis of indomethacin precursor

We developed an efficient method for synthesis of substituted N-benzoylindole via Pd(II)-catalyzed C-H functionalization of substituted N-(2-allylphenyl)benzamide. The reaction showed a broad substrate scope (including N-acetyl and N-Ts substrates) and substituted indoles were obtained in good to excellent yields. The most distinctive feature of this method lies in the high selectivity for N-benzoylindole over benzoxazine, and this is the first example of Pd(II)-catalyzed synthesis of substituted N-benzoylindole. Notably, this new method was applied for the synthesis of key intermediate of indomethacin.

Synthesis of Benzofuran and Indole Derivatives Catalyzed by Palladium on Carbon

Benzofurans and indoles are key moieties in many natural products and pharmaceuticals. Herein, we describe a cheap and easy-to-execute strategy for the synthesis of benzofurans and indoles, employing Pd/C as the promoter. A variety of substituted allyl-anilines and allyl-phenols were converted into the desired products in good to excellent yields. Recycling of Pd/C was possible up to five cycles, keeping similar levels of reactivity.

Green Organocatalytic Synthesis of Indolines and Pyrrolidines from Alkenes

Employing a green and efficient 2,2,2-trifluoroacetophenone-catalyzed oxidation of alkenes, which utilizes H2O2 as the green oxidant, a novel and sustainable synthesis of indolines and pyrrolidines was developed. This constitutes a cheap, general and environmentally-friendly protocol for the synthesis of substituted nitrogen-containing heterocycles. A variety of substitution patterns, both aromatic and aliphatic moieties, are well tolerated leading to the desired nitrogen heterocycles in good to excellent yields. (Figure presented.).