5984-95-2 Usage
Description
(-)-Isoproterenol hydrochloride, also known as Levophed, is a synthetic, non-selective beta-adrenergic agonist. It is a medication that primarily stimulates the beta-1 and beta-2 adrenergic receptors, leading to increased heart rate, contractility, and relaxation of smooth muscles, particularly in the bronchi and blood vessels. (-)-ISOPROTERENOL HYDROCHLORIDE is structurally similar to the naturally occurring hormone epinephrine (adrenaline) and norepinephrine (noradrenaline).
Uses
Used in Cardiology:
(-)-Isoproterenol hydrochloride is used as a medication for treating bradycardia, a condition characterized by an abnormally slow heart rate. It helps to increase the heart rate by stimulating the beta-1 adrenergic receptors, improving cardiac output and overall circulation.
Used in Respiratory Medicine:
(-)-Isoproterenol hydrochloride is used as a bronchodilator for the treatment of asthma and other respiratory conditions characterized by constriction of the airways. By stimulating the beta-2 adrenergic receptors, it helps to relax the smooth muscles surrounding the bronchi, allowing for easier breathing and improved oxygen flow.
Used in Emergency Medicine:
In emergency situations, (-)-Isoproterenol hydrochloride may be administered to counteract the effects of certain types of drug overdose, particularly those involving beta-blockers. Its agonist properties can help to reverse the negative effects of beta-blockade, such as severe bradycardia or hypotension.
Biochem/physiol Actions
Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate.
Check Digit Verification of cas no
The CAS Registry Mumber 5984-95-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,8 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5984-95:
(6*5)+(5*9)+(4*8)+(3*4)+(2*9)+(1*5)=142
142 % 10 = 2
So 5984-95-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1
5984-95-2Relevant articles and documents
Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis
Cui, Yan,Ma, Xiaowei,Zhao, Min,Jiang, Zhen,Xu, Shuying,Guo, Xingjie
, p. 409 - 414 (2013/07/26)
In the present study, hydroxypropyl-β-cyclodextrin and an ionic liquid (1-ethyl-3-methylimidazolium-l-lactate) were used as additives in capillary electrophoresis for the enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine hydrochloride, isoprenaline hydrochloride, chlorpheniramine maleate, liarozole, tropicamide, amlodipine benzenesulfonate, brompheniramine maleate, and homatropine methylbromide. The effects of ionic liquid concentrations, salt effect, cations, and anions of ionic liquids on enantioseparation were investigated and the results proved that there was a synergistic effect between hydroxypropyl-β-cyclodextrin and the ionic liquid, and the cationic part of the ionic liquid played an important role in the increased resolution. With the developed dual system, all the enantiomers of 10 analytes were well separated in resolutions of 5.35, 1.76, 1.85, 2.48, 2.88, 1.43, 5.45, 4.35, 2.76, and 2.98, respectively. In addition, the proposed method was applied to the determination of the enantiomeric purity of S-ofloxacin after validation of the method in terms of selectivity, repeatability, linearity range, accuracy, precision, limit of detection (LOD), and limit of quality (LOQ). Chirality 25:409-414, 2013.
