5985-28-4 Usage
Description
Synephrine hydrochloride, also known as (±)-Synephrine, is an alkaloid with vasoconstrictor and metabolic activities. It is a pale beige solid that binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs) and exhibits both agonist and antagonist properties. Synephrine hydrochloride is known for its ability to induce contractions in isolated aortic rings, increase mean arterial pressure, and promote lipolysis in adipocytes.
Uses
Used in Pharmaceutical Industry:
Synephrine hydrochloride is used as an α-adrenergic receptor agonist and vasoconstrictor for its ability to induce contractions in isolated aortic rings and increase mean arterial pressure in rats. This makes it a valuable compound for the development of medications targeting cardiovascular conditions.
Used in Metabolic Applications:
Synephrine hydrochloride is used as a metabolic activator for its ability to induce lipolysis in isolated rat and human adipocytes. It also increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, which can enhance insulin-induced glucose consumption in muscle cells. This makes it a potential candidate for the development of treatments for metabolic disorders and obesity.
Used in Research and Development:
Synephrine hydrochloride is used as a research compound for studying the effects of adrenergic receptor agonists and antagonists on various physiological processes. Its dual agonist and antagonist properties make it a valuable tool for understanding the complex interactions between these receptors and their roles in health and disease.
Check Digit Verification of cas no
The CAS Registry Mumber 5985-28-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,8 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5985-28:
(6*5)+(5*9)+(4*8)+(3*5)+(2*2)+(1*8)=134
134 % 10 = 4
So 5985-28-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
5985-28-4Relevant articles and documents
Synthesis and uses of synephrine derivatives
-
Page/Page column 21, (2008/06/13)
The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by β3-adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.